PhD Candidate in Cell-free Synthetic Biology Radboud University, Faculty of Science Netherlands

PhD Candidate in Cell-free Synthetic Biology 


Faculty of Science 

Maximum salary: € 2,972 gross/month 

Vacancy number: 62.09.19 

Application deadline: 5 May 2019



As a PhD candidate you will carry out research in the specified field under professorial supervision. You will report and publish your research findings in a number of articles during the course of your PhD. These articles will form part of your doctoral thesis, which you will defend at the end of your research in order to obtain the title of doctor. In addition to your research activities you will be expected to take part in the Institute of Molecules and Materials (IMM) education programme. As part of this programme you will develop various soft skills. Training topics include ethics, planning and teaching skills. You will also broaden and deepen your knowledge by participating in symposia, colloquia and summer schools. Moreover, you will be involved in the teaching of Bachelor’s and Master’s students.


Work environment

The research project is part of the Research Center for Functional Molecular Systems (FMS), a partnership of the organic and macromolecular chemistry teams at Eindhoven University of Technology, Radboud University Nijmegen and the University of Groningen, brought together to extend the frontiers of chemical self-assembly. You will be appointed to the chair group of Biophysical Chemistry led by Prof. Tom de Greef. You will work together with PhD candidates in the Physical Organic Chemistry group of Prof. Wilhelm Huck. 

Synthetic biology is a new interdisciplinary field involving the application of engineering principles to biology. Cell-free synthetic biology based on the use of bacterial cell lysate has emerged as a powerful tool for prototyping genetic networks in a controlled biochemical context, as well as for predicting cellular responses to such networks. In this project, you will design and prototype RNA-based regulatory genetic circuits using bacterial cell lysate in microfluidic flow reactors. The behaviour of these circuits will be compared to their behaviour in living bacteria. Relevant literature: Dubuc et al. (2018) Curr. Opin. Biotechnol. doi: 10.1016/j.copbio.2018.10.006., Yelleswarapu et al. (2018) ACS Synth. Biol. doi: 10.1021/acssynbio.8b00300.


What we expect from you

You should have:

  • good communication skills and be able to operate in a dynamic international research team;

  • an MSc degree in life sciences (biology, microbiology, biotechnology or a related field);

  • proficiency in written and spoken English;

  • knowledge of cloning, transformation of bacteria and culturing of bacteria is required;

  • knowledge of microfluidics and kinetic modelling of genetic circuits is an advantage.


What we have to offer

  • employment: 0.8 - 1.0 FTE;

  • a maximum gross monthly salary of € 2,972 based on a 38-hour working week;

  • the gross starting salary amounts to €2,325 per month, and will increase to €2,972 in the fourth year;

  • in addition to the salary: an 8% holiday allowance and an 8.3% end-of-year bonus;

  • duration of the contract: 4 years;

  • your performance will be evaluated after 18 months. If the evaluation is positive, the contract will be extended by 2.5 years;

  • you will be classified as a PhD Candidate (promovendus) in the Dutch university job-ranking system (UFO);

  • you will be able to make use of our Dual Career Service where our Dual Career Officer will assist with family related support, such as child care, and help your partner prepare for the local labour market and with finding an occupation.


Are you interested in our excellent employment conditions?

Would you like to know more?

Further information on: Biophysical Chemistry

For more information about this vacancy, please contact: 
Prof.dr. T.F.A. de Greef

Dr. H.A. Heus, Assistant Professor

Are you interested?

You should upload your application (attn. of prof.dr. T.F.A. de Greef) exclusively using the button 'Apply' below. Your application should include (and be limited to) the following attachment(s):

  • Letter of motivation

  • CV

If you apply for this position please say you saw it on Bioloxy


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