PhD Position in Bioactive and Transmembrane Peptides
University of Gothenburg Faculty of Science
Sweden

PhD Student in Bioactive and Transmembrane Peptides

Diary id: PAR 2020/367
Employment level: Fixed term
Location: Department of Chemistry and Molecular Biology
Apply by: 2020-04-07

A third cycle education at our department will lead to a Ph.D. in Natural sciences, or Natural sciences with a specialisation in Chemistry, Biology or Biophysics. Ph.D. studies comprises four years at the post graduate level. The time period can be extended to 5 years in total through teaching and/or other departmental duties.

We are seeking a highly motivated and talented person for functional studies of bioactive and transmembrane peptides. Bioactive peptides can be derived from various sources, including the venom of spiders, snakes or cone snails. The components of the venom are peptides of 20-30 amino acids and are usually very selective towards their targets, usually transmembrane proteins. The objective of this project is to explore the function of selected bioactive peptides, design of their analogs and use developed in our lab synthetic strategies for production of transmembrane proteins.

Methods:

  • Solid phase peptide synthesis
  • Liquid-phase synthesis (Organic chemistry)
  • Engineering of peptide mimetics
  • Peptide purification/ analysis: analytical and preparative HPLC, Mass spectrometry (ESI)
  • CD and NMR spectroscopy
  • Bioactivity/interaction assays: FRET, HPLC-based assays

The candidate will be part of a Wallenberg Centre for Molecular and Translational Medicine in Gothenburg (https://wcmtm.gu.se/)

Subject area: peptide chemistry/ characterization/ bioactivity/ interaction studies/ structure determination

Job assignments

The candidate will design/synthesize/ characterize bioactive and transmembrane peptides.

Eligibility

Applicants should have a Master’s degree in Chemistry, Biomolecular engineering, Biochemistry, Biotechnology or Pharmacy. We are seeking for highly motivated people with a competitive CV, capacity for team working and ability to perform independent work. Applicant should have an integrative and cooperative personality with enthusiasm for actively participating in interdisciplinary network with very good communication and writing skills (English). The employment is limited (temporary), full time and is placed at the Department of Chemistry and Molecular Biology (https://cmb.gu.se/english) within the Wallenberg Centre of Molecular and Translational Medicine (https://wcmtm.gu.se/research-groups/-tietze-group) .

The specific entry requirements also include an acceptable command of spoken and written English. Guidelines for assessing English proficiency may include a minimum score of 550 on the TOEFL test (or 213 on the TOEFL-CBT, or 79 on the TOEFL-iBT).

Assessment

The applicant must have a background in organic chemistry. Experience in peptide chemistry, peptide analytics (RP-HPLC, LC-MS), bioactivity assays and/or protein expression techniques is beneficial. The successful applicant is expected to plan, execute and analyse experiments in an independent manner and to actively contribute scientifically to the group. Candidates must have excellent oral and written communication skills in English

Employment

Type of employment: Fixed-term employment, Four years full time
Extent: 100 %
Location: Department of Chemistry and Molecular Biology, Gothenburg
First day of employment: as agreed upon

Regulations for the evaluation of qualifications for education on a doctoral level are given in SFS 1998:80.

A new employment as a PhD student applies for a maximum of one year. The Appointment may be prolonged for up to two years at a time. The total employment period may not be longer than the equivalent of four years of full time time doctoral studies.

University applies local agreement on salaries of graduate students.

Appointment procedure

Please apply online

The application shall include:

Cover letter with an explanation of why you apply for the position
CV including scientific publications
Copy of exam certificate
Two references (name, telephone no, relation)

For further information regarding the position

Regarding the position please contact: Alesia A. Tietze, Associate Senior Lecturer, alesia.a.tietze@gu.se
+46 31 786 6248

Regarding the appointment procedure, please contact: Catarina Mörck, HR, catarina.morck@cmb.gu.se

Unions

Union representatives at the University of Gothenburg: http://www.gu.se/english/about_the_university/job-opportunities/union-representatives

How to apply

In order to apply for a position at the University of Gothenburg, you must register an account in our online recruitment system. It is the responsibility of the applicant to ensure that the application is complete in accordance with the instructions in the job advertisement, and that it is submitted before the deadline. The selection of candidates is made based on the qualifications registered in the application.

The application is to be written in English.

Closing date 2020-04-07


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