PhD Position in Tumor Immunology
University of Bern Department for BioMedical Research
Switzerland

PhD Student in Tumor Immunology Laboratory

Department of Medical Oncology/Department for BioMedical Research (DBMR)

University of Bern, Switzerland

Is looking for as soon as possible or as agreed upon
Limited time for 4 years (Salary based on the regulation by the Swiss National Science Foundation)

Our research group investigates the interaction of immune cells with leukemia and cancer stem cells. A special focus of our work comprises the analysis of so-called cancer stem cells. These cells are the origin of the disease and the main reason for relapse after initial response to therapy. Aim of our re-search is to improve and develop immunotherapies for cancer patients. Our research makes primarily use of syngeneic tumor mouse models and primary patient material. The position offers a brought insight into translational research starting from animal models to clinical application.

The challenge

We have an open position for a highly motivated PhD student in our lab. The focus of the work is the translation and validation of immune-related targets identified in pre-clinical settings towards clinical application. The aim of the projects will be the functional characterization of immune-related receptors on leukemia stem cells and evaluating the potency of targeting these receptors on leukemia stem cells using monoclonal antibodies, bi-specific T cell engagers and CAR T cells. These translational research projects will provide opportunities to learn and use state-of-the-art techniques in immunology (e.g. FACS analysis), molecular biology (e.g. CRISPR and RNA sequencing) and stem cell biology (e.g. colony formation assays).

Your profile

The successful applicant is expected to have a Master degree in biological sciences or related disci-plines and experience in NK cell and T cell biology and immunological techniques (e.g. FACS, T/NK cell assays) as well as molecular biology techniques such as qRT-PCR and next-generation RNA sequencing. Experience with mouse handling and experimentation are desirable.

The package

Young, dynamic team and attractive, varied working conditions.

Contact and application

Contact: Prof. A. F. Ochsenbein, Prof. Dr. sc. nat. C. Riether, Tumor Immunology Laboratory, Department for BioMedical Research (DBMR), Murtenstrasse 35, MEM D806, 3010 Bern

Please only apply online. Code number 12542.


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