Post Doc in Biophysics
Technical University of Munich
Germany

PhD / PostDoc in biophysics

03.05.2021, Wissenschaftliches Personal

Living cells rely on the ability of the cytoskeleton to continuously form and destroy diverse structures, which is strongly coupled to the adhesion processes. The group of Prof. Bausch studies the physical basis of the underlying self-organization processes and is looking for a PhD student/Postdoc (f/m) The Mission Generated from different types of stem cells, derived from different species and different tissues, organoid culture represents a versatile tool for studying tissue development, homeostasis and regeneration. In addition, organoid generation from healthy as well as diseased tissue can serve the development of therapeutic approaches in a pre-clinical stage by offering high-throughput drug screening platforms. Organoids generated in a 3D environment closely recapitulate cellular composition and tissue architecture such as the ductal morphology of branched organs such as pancreas and mammary gland. Growth, differentiation and morphology thereby rely on a tight regulation of cell-ECM and cell-cell adhesion, which need to be well-orchestrated with the growth and aggregation process of the cytoskeleton. In close collaboration with colleagues from cell biology, we aim to understand the role of balance between cell-ECM and cell-cell adhesion in the organoid growth process and how it influences cellular migration patterns during the process of self-organization. The ultimate goal is to understand the physical principles of the dynamic adaption of the adhesion processes. Therefore, we take an interdisciplinary approach and use organoid cultures from both human and mice, high resolution microscopy, and mathematical modelling to address the following questions: - How do cells coordinate proliferation and motility during organoid development? - What is the role of ECM-mediated constrain in the self-organizational process? - How is the cell differentiation regulated by morphological aspects during organoid growth? For more information go to: https://www.bauschlab.org Your responsibilities/tasks: - Establishment and usage of cutting-edge 3D cell culture methods including culturing of primary human and murine cells - Establishment of molecular techniques such as cloning, viral transfection, CRISPR/Cas9-mediated gene editing - Biochemical analysis of protein expression, localization and interaction in 2D and 3D culture systems - Manipulation of cell-ECM adhesion and cell-cell interaction - Advanced methods of light microscopy and digital imaging processing and analysis Your Qualification: - High motivation, curiosity, and commitment to scientific excellence - Master's degree in cell biology, biochemistry, medicine, biophysics or similar fields - Practical lab experience, ideally cell culture experience - Interest in interdisciplinary and quantitative biology - Excellent skills in spoken as well as written English Our offer Remuneration and benefits in accordance with the collective agreement for the public service (TV-L13, 75%). The position is (initially) limited to three years. As a holder of the Total E-Quality Award, we promote equality of opportunity. In order to increase the proportion of women in management positions, we would be pleased to receive corresponding applications. Qualified applicants with physical disabilities will be given preference. We are looking forward to receiving your comprehensive application preferably per E-mail (e27applications@ph.tum.de).

The Mission

Generated from different types of stem cells, derived from different species and different tissues, organoid culture represents a versatile tool for studying tissue development, homeostasis and regeneration. In addition, organoid generation from healthy as well as diseased tissue can serve the development of therapeutic approaches in a pre-clinical stage by offering high-throughput drug screening platforms.

Organoids generated in a 3D environment closely recapitulate cellular composition and tissue architecture such as the ductal morphology of branched organs such as pancreas and mammary gland.

Growth, differentiation and morphology thereby rely on a tight regulation of cell-ECM and cell-cell adhesion, which need to be well-orchestrated with the growth and aggregation process of the cytoskeleton. In close collaboration with colleagues from cell biology, we aim to understand the role of balance between cell-ECM and cell-cell adhesion in the organoid growth process and how it influences cellular migration patterns during the process of self-organization. The ultimate goal is to understand the physical principles of the dynamic adaption of the adhesion processes.

Therefore, we take an interdisciplinary approach and use organoid cultures from both human and mice, high resolution microscopy, and mathematical modelling to address the following questions:

- How do cells coordinate proliferation and motility during organoid development?
- What is the role of ECM-mediated constrain in the self-organizational process?
- How is the cell differentiation regulated by morphological aspects during organoid growth?

For more information go to: https://www.bauschlab.org

Your responsibilities/tasks:

- Establishment and usage of cutting-edge 3D cell culture methods including culturing of primary human and murine cells
- Establishment of molecular techniques such as cloning, viral transfection, CRISPR/Cas9-mediated gene editing
- Biochemical analysis of protein expression, localization and interaction in 2D and 3D culture systems
- Manipulation of cell-ECM adhesion and cell-cell interaction
- Advanced methods of light microscopy and digital imaging processing and analysis

Your Qualification:

- High motivation, curiosity, and commitment to scientific excellence
- Master's degree in cell biology, biochemistry, medicine, biophysics or similar fields
- Practical lab experience, ideally cell culture experience
- Interest in interdisciplinary and quantitative biology
- Excellent skills in spoken as well as written English

Our offer

Remuneration and benefits in accordance with the collective agreement for the public service (TV-L13, 75%).

The position is (initially) limited to three years.

As a holder of the Total E-Quality Award, we promote equality of opportunity. In order to increase the proportion of women in management positions, we would be pleased to receive corresponding applications. Qualified applicants with physical disabilities will be given preference.

We are looking forward to receiving your comprehensive application preferably per E-mail (e27applications@ph.tum.de).

Hinweis zum Datenschutz:

Im Rahmen Ihrer Bewerbung um eine Stelle an der Technischen Universität München (TUM) übermitteln Sie personenbezogene Daten. Beachten Sie bitte hierzu unsere Datenschutzhinweise gemäß Art. 13 Datenschutz-Grundverordnung (DSGVO) zur Erhebung und Verarbeitung von personenbezogenen Daten im Rahmen Ihrer Bewerbung. Durch die Übermittlung Ihrer Bewerbung bestätigen Sie, dass Sie die Datenschutzhinweise der TUM zur Kenntnis genommen haben.

Kontakt: Prof. Dr. Andreas Bausch, abausch@mytum.de

Mehr Information

http://www.bauschlab.org

 


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