Post Doc in Neurobiology
Catholic University of Leuven
Belgium

 
The laboratory of Cellular Transport Systems, headed by Prof. Peter Vangheluwe, recently published ground-breaking insights in the underlying molecular and cellular defects in Parkinson’s disease (Van Veen and Martin et al, Nature, 2020; Martin and Smolders et al, Acta Neuropathologica, 2020). Research of his team focuses on the P-type ATPases ATP13A2 (PARK9) and ATP10B, two transporters that are genetically implicated in Parkinson’s disease. They’ve established that ATP13A2 removes polyamines out of the lysosome, whereas ATP10B is a lysosomal exporter of the sphingolipid glucosylceramide; both lysosomal functions exert potent neuroprotective effects. Based on these novel molecular insights we will study the phenotype of ATP13A2 and ATP10B KO mouse models, and investigate cross-talk with other established pathways of neurodegeneration. This study is part of the research project IMPACT-PD, a highly prestigious and international collaborative research initiative funded by the Aligning Science Across Parkinson’s (ASAP) program.

Responsibilities

Within the ASAP program we recruit a highly skilled and motivated junior/senior postdoc to strengthen the multidisciplinary team of academic partners. In particular, we look for an experienced Neurobiologist to characterize the phenotype and pathways of neurodegeneration in ATP13A2 and ATP10B KO mice, while performing omics analyses on tissue and biofluids.

Profile

  • Experience with mouse models of neurodegeneration (Immunohistochemistry, behavioral phenotyping, mice breeding), a background in Parkinson’s disease mechanisms, and lysosomal/mitochondrial biology are strong assets
  • PhD degree (max 5 years) in Medical or Biomedical Sciences, Bioengineering, (Neuro)biology, or equivalent.
  • A curious and creative mind set, eager to learn
  • Perseverant with good problem-solving skills
  • Ambitious, ability to take ownership of the project
  • Good time and project management skills to adhere to strict project deadlines and milestones.
  • Proven proficiency in English, both written and orally
  • Experienced in project management
  • Effective communicator, reporting results in the team and in consortium meetings
  • Leadership skills, able to inspire and motivate people
  • Excellent team player, working in an international and multidisciplinary team to reach common goals

Offer

  • A full-time appointment (100%) as a post doc for a period of 3 years with the possibility of an extension. The successful candidate is encouraged to initiate and participate in grant proposals to expand the research line and ensure continuation after the project end.
  • Affiliation to a world-renowned laboratory in transport biology with an extensive international and collaborative network.
  • Participation in a prestigious international research network ASAP with focus on collaboration and open science, offering excellent networking opportunities.
  • The possibility to participate and present your research at national and international conferences.

Interested?

For more information regarding our work, please check out:

Lab website: https://www.labcelltransport.com/

ASAP project and team info: https://parkinsonsroadmap.org/research-network/biology-of-pd-associated-genetics/

For more information please contact Prof. Dr. Peter Vangheluwe, tel.:+32 16 33 07 20, mail: peter.vangheluwe@kuleuven.be or Mrs.Veronique Daniëls, tel.: +32 16 32 63 65, mail: veronique.daniels@kuleuven.be.

You can apply for this job no later than November 09, 2020 via the
KU Leuven seeks to foster an environment where all talents can flourish, regardless of gender, age, cultural background, nationality or impairments. If you have any questions relating to accessibility or support, please contact us at diversiteit.HR@kuleuven.be.
  • Employment percentage: Voltijds
  • Location: Leuven
  • Apply before: November 9, 2020
  • Tags: Cellulaire en Moleculaire Geneeskunde


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