Postdoc Position in Quantitative Cell Biology of Genome Integrity Research
Universität Zürich Department of Molecular Mechanisms of Disease
Switzerland

Postdoc Position in Quantitative Cell Biology of Genome Integrity Research
100 %


Our department with its research focus on chromatin biology, intracellular signaling, epigenetic regulation, and genome integrity maintenance is integrated into the natural sciences campus of the University of Zurich, the biggest University in Switzerland and one of Europe's leading research centers. On-site core facilities offer easy access to state-of-the-art technologies in genomics, transcriptomics, epigenomics, proteomics, cytometry and advanced microscopy. The successful candidate will join a young and dynamic international team of dedicated scientists and benefit from a highly collaborative research atmosphere. Career development and a competitive salary plus social benefits will be offered.

 


Your responsibilities

 


Research in the Altmeyer lab aims at elucidating mechanisms how mammalian cells protect their genome from attrition and instability. When cells experience replication srtress or DNA damage they activate a sophisticated molecular signaling network to shield genomic lesions, promote appropriate repair reactions, and coordinate restoration of genome integrity with cell cycle progression. In order to study these processes and their dynamics, we employ quantitative high-content single cell and cell population imaging in conjunction with gene perturbation screens, CRISPR/Cas9-mediated gene targeting, live cell microscopy, targeted proteomics, and molecular biology and biochemistry. Projects are at the intersection of the DNA damage and replication stress response, chromatin and protein dynamics, and nuclear organisation by liquid-liquid phase separation (see also Teloni et al. Mol Cell. 2019, Michelena et al. Nature Comm. 2018; Pellegrino et al. Cell Reports. 2017; Altmeyer et al. Nature Comm. 2015).

 


Your profile

 


Candidates should hold or expect to be awarded a Ph.D. or equivalent degree in natural or biomedical sciences. Applicants should have a strong scientific track record with at least one publication as first author in a peer reviewed journal. Prior experience with mammalian cell culture and standard molecular biology techniques is expected. A background in chromatin biology, genome stability maintenance, DNA replication, or intracellular phase separation is a plus. The successful candidate will have excellent communication and writing skills, a curiosity-driven attitude, a high level of motivation, and demonstrate enthusiasm, flexibility and independence. English (fluent) and Computer skills basics.

 


What we offer


Full-time postdoc position to achieve further academic qualifications.


For additional information about an employment at the University of Zurich please visit http://www.pa.uzh.ch/en/Willkommen-an-der-UZH.html

 


Place of workZurich

 


Start of employment
Immediately or upon agreement. Applications will be considered on a rolling basis.


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