Postdoctoral Research AssistantDepartment: Barts Cancer Institute Overview:Centre for Cancer Evolution and Computational Biology Dr. Benjamin Werner from the Barts Cancer Institute in London is searching for a Post Doc candidate to join his team at Queen Mary University in London. The Postdoctoral Research Assistant position is funded for 3 years by the Human Frontiers in Science Program and part of a joined collaboration (ADAPTSEX) with Thorsten Reusch from Geomar in Kiel (Germany) and Iliana Baums from Penn State University (USA). In this international collaboration we develop and integrate population genetics theory on somatic evolution with genomic/experimental data on seagrasses and corals to understand the role of somatic evolution on the adaptation of these long lived asexual organisms. The Post Doc positions searches for a mathematical/computational biologist with knowledge in cancer genetic population theory and ideally experience with cancer genomic data. The aim is to further develop the ideas and concepts of genetic somatic evolution and integrate those models with cancer, seagrass and coral data. All multicellular species are genetic mosaics, composed of cell lines that differ in their genotype owing to somatic mutations. Such intra-organismal genetic heterogeneity is often viewed negatively, resulting in mutational load, fitness decreases and senescence. Arguably the most prominent case is cancer that is now commonly viewed as evolutionary process. Within this framework, recent progress in modeling adaptive dynamics was made, describing important sub-clonal genetic structure, and identify driver and passenger mutations in growing cancer tumors. To exchange knowledge among the biomedical field and the evolutionary ecology of free-living, “natural” clones, two evolutionary ecologists working in plant (Thorsten Reusch) and coral (Iliana Baums) evolutionary ecology and genomics have therefore teamed up with me. In ADAPTASEX, we will develop a joint analytical framework to comprehensively describe adaptive dynamics in multicellular clonal systems by bringing together researchers from cancer to corals and seagrasses. At Queen Mary University of London, we believe that a diversity of ideas helps us achieve the previously unthinkable. We offer competitive salaries, access to a generous pension scheme, 30 days’ leave per annum (pro-rata for part-time/fixed-term), a season ticket loan scheme and access to a comprehensive range of personal and professional development opportunities. In addition, we offer a range of work life balance and family friendly, inclusive employment policies, flexible working arrangements, and campus facilities including an on-site nursery at the Mile End campus. Valuing Diversity & Committed to Equality Apply online
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