Postdoctoral Scholar for Epigenomic Mechanisms of Memory Disruption by Early-life Seizures
University of California, Irvine, School of Medicine - Anatomy & Neurobiology
United States

Postdoctoral Scholar for Epigenomic Mechanisms of Memory Disruption by Early-life Seizures


  • School of Medicine - Anatomy & Neurobiology



Open February 14th, 2019 through Sunday, Jun 30, 2019 at 11:59pm (Pacific Time)


A postdoctoral position is offered in a vibrant Neuroscience laboratory to probe the transcriptional and epigenetic mechanisms initiated by early-life seizures that differentially program newborn and mature hippocampal dentate gyrus granule cells and pyramidal neurons. These changes cause significant disruption of hippocampus-dependent memory processes associated with Epilepsy, with major clinical importance.


The NIH-funded project will employ innovative methodologies to examine, at single cell resolution, the role of specific transcription factors in functional and structural hippocampal derangements that promote memory problems. ChIP-seq, single-cell RNA-seq and subsequent interventional approaches will be employed. Additional methods used in the lab include DREADD technology, live 2-photon imaging, as well as DTI imaging and behavioral testing.


(See: Patterson et al., J Neurosci, 2017;, McClelland et al., eLife 2014; Singh-Taylor et al., Molec Psych 2018; Bolton et al., Biol Psych 2018; Dube et al., Trends Neurosci, 2007).


The culturally diverse and welcoming laboratory is located on the UC Irvine campus, a rich community of Molecular and Neuroscience research within Southern California.


Candidates should have a recent PhD degree and experience in Molecular Biology, and must be highly motivated. Experience in Bioinformatics and Neuroscience is desirable.


To Apply, please visit:


Please upload a CV, a brief statement of research accomplishments and interests, and a list of references.


Thank you,
Tallie Z. Baram, MD, PhD
D.D. Shepard Professor of Neurological Sciences
Prof. Pediatrics, Anatomy/ Neurobiology, Neurology
University of California-Irvine, CA, USA


The University of California, Irvine is an Equal Opportunity/Affirmative Action Employer advancing inclusive excellence. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected categories covered by the UC nondiscrimination policy.



Irvine, CA



Document requirements
  • Curriculum Vitae - Your most recently updated C.V.

  • Cover Letter (Optional)

  • Statement of Research - Please make sure to highlight research accomplishments and interests.

  • Statement of Teaching - See our guidance for writing a reflective teaching statement. 

  • Statement of Contributions to Diversity - Statement addressing how past and/or potential contributions to diversity will advance UCI's Commitment to Inclusive Excellence.

  • Misc / Additional (Optional)

Reference requirements
  • 3-5 required (contact information only)



  1. Create an ApplicantID

  2. Provide required information and documents

  3. If any, provide required reference information

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