Research Fellow in the Centre for Cancer Research
The University of Edinburgh - Centre for Cancer Research
United Kingdom

We are looking for a motivated and creative postdoctoral researcher to drive an exciting new research project at the interface of molecular biology, biochemistry and cell biology. The position is full time for three years and will be available from September 2019. The project is aimed at understanding a novel nucleoli-NF-kappaB signalling pathway and the role this pathway plays in the anti-tumour effects of aspirin and in aging and senescence. High content imaging, single cell transcriptomics and biochemical approaches will be used to understand how nucleoli influence cellular homeostasis and the relevance of this to aging and disease. The work will be undertaken as part of a research team led by Dr Lesley Stark and is funded by a BBSRC project grant, in collaboration with Dr Tamir Chandra (IGMM, Edinburgh).


The successful applicant will have a PhD (or near completion) in cell signalling, imaging, nucleolar biology, or a related area and have relevant research publications. They will be expected to design, execute, analyse and interpret experiments; produce materials for publication and dissemination; and present data at a local and national/international level. Duties will also include training and supervision of students and new lab members.

Informal enquiries to Lesley.Stark@ed.ac.uk are encouraged.

This post is available on a fixed term basis for 36 months.


Job Purpose

The post holder is expected to drive a high quality research project at the interface of molecular biology, biochemistry and cell biology. The project will be directed towards understanding a new nucleoli-NF-kappaB signalling pathway and the role this pathway plays in the anti-tumour effects of aspirin and in aging and senescence. He/She will conduct original research and produce materials for publication and dissemination. Involvement in other project related activities (e.g. training and supervision, public engagement etc.) will also be required.


Main Responsibilities

• To design and implement assays to understand autophagic degradation of TIF-IA and how this links to NF-kB activity using multiple molecular biologic, microscopic and biochemical assays, including phenotypic screens. Analyse the data generated to progress the study. This requires keeping up to date with the literature in the field.

• Maintain accurate and up-to-date records to document the research progress

• Take a lead role in writing up data for patent protection or publication in peer-reviewed journals

• Present data at group and section meetings

• Contribute to the dissemination of research at national and international meetings

• To provide guidance and supervision for student projects and instruction of students

Planning and Organising

With the guidance of the line managers, the post holder will plan and manage his/her own programme of research activity, to ensure that the research is conducted in accordance with the research timetable.


Problem Solving

The post holder is expected to resolve most problems using accumulated experience, with only the more challenging, non-standard issues reported to the line manager for assistance. To use creativity, initiative and knowledge to identify areas for research, develop new research methods, and diversify the research parameters. Use initiative and experience to analyse and interpret research data, and draw conclusions from it. Use initiative to help other researchers in the team to resolve project problems and develop new techniques and methods, as appropriate.


Decision Making

Taken independently: Organise own workload according to priority and adapt as necessary, setting of short-term time-lines, design experimental set-up to address specific research aims

Level of Direction Given: Dr Stark, as primary line manager, will offer orientation and advice, in addition to support in developing and implementation of the research strategy.


Key Contacts/Relationships

Internal: Dr Stark (Primary line Manager). Dr Chandra (second Line manager). Other members of the Stark and Chandra Groups. Other laboratories within the Cancer Centre, MRC IGMM and across the University.

External: Participate in collaborations in Edinburgh, nationally and internationally.

Knowledge, Skills and Experience Needed for the Job

Knowledge.

Essential:

• PhD (or near completion) in Cancer cell biology, cell signalling or related disciplines

• Proven track record of scientific publication and conference presentations.

Skills and experience

Essential:

• Basic molecular/cell biology techniques

• Experience in microscopy

• Cancer cell signalling

Desirable:

• Cell culture and phenotypic assays

• Image quantification

• Nucleolar biology

• Senescence

• Bioinformatic analysis of proteomic datasets

Dimensions

• Interacting with other members of the Stark and Chandra groups.

• Interacting with Group’s collaborators in the UK and internationally.

• Active participation in critical discussion at group, section and Institute meetings.

• Produce data for first author publications in high impact journals.

• Present data at appropriate national and international meetings

Job Context and any other relevant information

The post-holder will join a small, but well established and enthusiastic lab that is exploring an exciting new pathway that has relevance to the anti-tumour effects of aspirin, as well as senescence and aging. He/She will also be a part of a new dynamic lab exploring signalling networks in senescence and aging using single cell transcriptomics. The position will be held within the multidisciplinary environment of the Edinburgh Cancer Research UK Centre/MRC IGMM.


Salary

The role is grade UE07 and attracts an annual salary of £33,199 to £39,609 for 35 hours each week. Salary is paid monthly by direct transfer to your Bank or Building Society account, normally on the 28th of the month. Salaries for part-time staff are calculated on the full-time scales, pro-rata to the Standard Working Week.


Application Procedure

All applicants should apply online at www.ed.ac.uk/jobs The application process is quick and easy to follow, and you will receive email confirmation of safe receipt of your application. Please submit your CV with your application.


ELIGIBILITY TO WORK

In accordance with the Immigration, Asylum and Nationality Act 2006 the University of Edinburgh, as an employer, has a legal responsibility to prevent illegal working and therefore must check that all employees are entitled to work in the United Kingdom (UK).

To do so, the University of Edinburgh requires to see original documents evidencing right to work in the UK before commencement of employment and this is normally carried out at interview. Details will be provided in any letter of invitation to interview.

 

Institute of Genetics & Molecular Medicine

MRC Institute of Genetics & Molecular Medicine at the University of Edinburgh (IGMM) The IGMM (Director, Professor Margaret Frame, FRSE FMedSci) was formed in 2007, as a consequence of a strategic alliance between the MRC, the University of Edinburgh and Cancer Research UK.

The IGMM constitutes one of the largest aggregates of human molecular genetics and biology research capacity in the UK with over 70 Principal Investigators and 500 staff and PhD students. By pooling the resources and complementary skills of the constituent centres, IGMM brings together the scientific expertise, technology and support services needed to maximise scientific discovery.

The Institute enables rapid translation of basic scientific discoveries into new treatments, clinical guidelines and innovative products that have significant impact on the society in the UK and Worldwide.

http://www.ed.ac.uk/igmm/


Salary

The role is grade Ue07 and attracts an annual salary of £33,199 to £39,609 for 35 hours each week. Salary is paid monthly by direct transfer to your Bank or Building Society account, normally on the 28th of the month. Salaries for part-time staff are calculated on the full-time scales, pro-rata to the Standard Working Week.

This post is available on a fixed term basis, with a working pattern of 35 hours per week for 36 months.


Pension Scheme

This role is grade Ue07 and therefore the post holder is automatically included in membership of the Universities Superannuation Scheme (USS), subject to the USS membership criteria, unless they indicate that they choose not to join the Scheme.

For further information please visit our pension’s website: http://www.ed.ac.uk/schools-departments/finance/pensions/scheme-details/uss


Right to Work

In accordance with the Immigration, Asylum and Nationality Act 2006 and Immigration Act 2016 the University of Edinburgh, as an employer, has a legal responsibility to prevent illegal working and therefore must check that all employees are entitled to work in the United Kingdom (UK).

To do so, the University requires to see original documents evidencing right to work in the UK before commencement of employment and this is normally carried out at interview. Details will be provided in any letter of invitation to interview.

For further information on right to work please visit our right to work webpage

If you are from outside the EEA and not currently eligible to work in the UK, there are visa routes that may be available to you, for example:

Tier 1 (Exceptional Talent): If you are an academic in the field of sciences; humanities; engineering; medicine; digital technology; or the arts, it may be possible for you to apply for a Tier 1 (Exceptional Talent) visa. This route requires you to apply to be endorsed as an internationally recognised leader or emerging leader in your particular field by a designated competent body (Arts Council England, British Academy, Royal Academy of Engineering, Royal Society, Tech City UK). However, if you are applying for a senior academic role, e.g. Professor/Reader there is an accelerated route to endorsement. Further information can be found on the UKVI website

Tier 2: The University is a UKVI licensed sponsor and is able to issue a Certificate of Sponsorship (CoS) to successful candidates who are offered highly skilled roles and meet the eligibility criteria. The CoS enables candidates to apply for a Tier 2 (general visa).

Please note if you were last granted leave to stay in the UK in any Tier 2 category in the 12 months immediately preceding an application and the leave has

• ended or expired.

• the CoS which led to that grant of leave was issued for more than 3 months, and

• you are either:

o applying for entry clearance from outside the UK, or

o you are in the UK and had a previous period of Tier 2 leave, but then changed (‘switched’) into a different immigration category and now wishes to apply again under Tier 2.

You must wait 12 months before applying again.

Further information about whether you require a visa and other visa routes can be found at: www.gov.uk/check-uk-visa

Application Procedure

All applicants should apply online by clicking the “apply” button at the foot of this page. The application process is quick and easy to follow, and you will receive email confirmation of safe receipt of your application. The online system allows you to submit a CV and other attachments.

Closing date: 12 August 2019 at 5pm.

The University reserves the right to vary the candidate information or make no appointment at all. Neither in part, nor in whole does this information form part of any contract between the University and any individual.

 

Deanery of Molecular, Genetic and Population Health Sciences

Molecular, Genetic and Population Health Sciences is one of three Deaneries in Edinburgh Medical School which, together with the Royal (Dick) School of Veterinary Studies, makes up the College of Medicine and Veterinary Medicine. The Deanery is headed by Professor Sarah Cunningham-Burley and comprises the Institute of Genetics and Molecular Medicine (IGMM), the Usher Institute of Population Health Sciences and Informatics, the Division of Pathology and the Edinburgh Clinical Trials Unit. The Deanery currently attracts annual research grants of around £40M, including a number of full programme grants, and has around 630 employees including 39 Professors, over 260 other academic members of staff and 330 members of support staff. The Deanery operates across three University of Edinburgh sites; the Western General Hospital campus, the Central Area, and Little France. Staff contribute undergraduate and postgraduate teaching and offer on-campus and on-line programmes. There is a vibrant PhD community in both IGMM and the Usher Institute.

Molecular, Genetic and Population Health Sciences

 

The College of Medicine and Veterinary Medicine

The College of Medicine and Veterinary Medicine The College of Medicine and Veterinary Medicine traces its origins back nearly 500 years (Darwin, Simpson and Conan-Doyle were students here) and is internationally renowned for its research and teaching. Professor Moira Whyte is the Head of College, the only conjoint Medical and Veterinary Medical School in the UK. The College employs over 3000 academic and support staff. The College has two Schools, the Edinburgh Medical School comprising 3 Deaneries; Biomedical Sciences; Molecular Genetic and Population Health Sciences and Clinical Sciences and the Royal (Dick) School of Veterinary Studies.

 

The Royal (Dick) School of Veterinary Studies

 

Edinburgh Medical School: Biomedical Sciences

 

Edinburgh Medical School: Biomedical Sciences, Biomedical Teaching Organisation

 

Edinburgh Medical School: Molecular, Genetic and Population Health Sciences

 

Edinburgh Medical School: Clinical Sciences

 

The undergraduate medicine teaching programme in the College enjoys a high reputation nationally and internationally, with over 1,300 students enrolled on the MBChB and Intercalated courses and nearly 1000 on the Veterinary Sciences BVS and related programmes. In addition, approximately 2000 students are currently enrolled in the College’s taught and research post-graduate courses, including an extensive range of online distance learning diplomas and degrees. They are trained by over 1000 outstanding academic staff. Details of PhDs, research programmes and studentships are available through our interdisciplinary research institutes and centres.

 

The academic disciplines within Medicine are largely concentrated in the two teaching hospital campuses, the Royal Infirmary at Little France and the Western General Hospital. Both have extensive new infrastructure with major research institutes and state of the art research facilities on clinical sites. Edinburgh hosts a number of prestigious MRC and BHF Research Centres. The approach is interdisciplinary, with basic and clinical researchers working together at the laboratory bench and in our clinical research facilities to address major themes in basic, clinical and translational medicine.

 

The Royal (Dick) School of Veterinary Studies on the Easter Bush Campus houses outstanding teaching and clinical facilities as well as the splendid Roslin Institute, one of the world’s leading veterinary research centres. The College offers outstanding opportunities to address ‘One Health’ and Global Health problems of the highest international priority.

 

Research Excellence Framework (REF) 2014

 

The College’s reputation as one of the world’s leading centres of medical and veterinary medical research has been reaffirmed by its UK REF2014 results. Medicine, the University’s largest submission, was ranked in the top 5 in the UK. Veterinary Medicine came 1st in the UK, and retained its position as the UK’s top Vet School. It made a joint submission with Scotland’s Rural College (SRUC). Neuroscience was ranked 3rd in the UK out of 82 submissions, representing a major advance. Overall, 84% of the College’s research activity was rated world leading or internationally excellent (3* and 4*). In terms of 'one medicine' research (human and animal medicine), the University of Edinburgh's research power (quality x volume) is the strongest in the UK.

 

The University of Edinburgh

For more than four centuries, our people and their achievements have rewritten history time and again. They’ve explored space, revolutionised surgery, published era-defining books, paved the way for life-saving medical breakthroughs and introduced to the world many inventions, discoveries and ideas from penicillin to Dolly the sheep. We have believed that anything is possible, we still do.

The latest Research Excellence Framework highlighted our place at the forefront of international research. This adds to our international reputation for the quality of our teaching and our student experience excellence. The University is proud of its success with online teaching initiatives, with 2550 students currently studying its online distance learning postgraduate programmes, and a total to date of more than 2 million enrolments for Edinburgh MOOCs.

 

As a member of staff, you will be part of one of the world's leading universities, with 20 Schools spread over 3 Colleges that offer more than 1600 undergraduate and 600 postgraduate programmes to over 41,000 students each year. Professional services are critical to this success as well as our world-class teaching, research and student facilities. In fact, we are one of the top employers in Edinburgh, with over 14,500 people spread across a wide range of academic and supporting roles.

 

As a world-changing, world-leading university, we offer an exciting, positive, creative, challenging and rewarding place to work. We give you support, nurture your talent, develop and reward success and integrate academic, professional and personal career goals, as well as give your career the benefit of a great and distinguished reputation. In addition, our employees benefit from a competitive reward package and a wide range of staff benefits, which include generous holiday entitlement, a defined benefits pension scheme, staff discounts and much more. Access our staff benefits page for further information and use our reward calculator to find out the total value of pay and benefits provided.

 

The University of Edinburgh holds a Silver Athena SWAN award in recognition of our commitment to advance gender equality in higher education. We are members of the Race Equality Charter and we are also Stonewall Scotland Diversity Champions, actively promoting LGBT equality. The University has a range of initiatives to support a family friendly working environment, including flexible working and childcare vouchers. See our University Initiatives website for further information.

 

University Family Friendly Initiatives

 

Equality Networks:

 

Staff Pride Network for LGBT+ colleagues and allies

Disabled Staff Network

 

The University of Edinburgh is a charitable body, registered in Scotland, with registration number SC005336.


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