Research Fellow in Biophysics of Cancer
University of Leeds School of Physics and Astronomy
United Kingdom

Research Fellow in Biophysics of Cancer

Are you an ambitious researcher looking for your next challenge? Do you have an established background in biological physics? Do you want to further your career at one of the UKs leading research-intensive Universities?

We are looking for a Research Fellow to work on an EPSRC-funded project with Dr Sally Peyman, in the Molecular and Nanoscale Physics Group, investigating biophysical mechanisms of drug resistance in solid tumours.

Pancreatic cancer is hallmarked by a dense, rigid tumour mass similar to that of scar tissue. The mechanical stiffness of the tumour is thought to directly contribute to treatment failure and poor survival rates. Yet despite the importance of these biophysical factors, they are rarely taken into account in drug development assays.

You will join an interdisciplinary team focussed on developing microfluidic organ-on-chip models for studying biophysical mechanisms of drug resistance in pancreatic cancer. Our goal is to investigate how the mechanical rigidity of pancreatic microtumours impedes drug delivery and develop tumour-on-chip devices that accurately mimic these physical barriers. Developing tumour-on-chip platforms will enable us to better understand why so many drugs fail in the clinic and provide advanced testbeds for the development of new therapies that overcome these drug delivery challenges.

You will use a range of experimental techniques, including cutting edge Atomic Force Microscopy and rheology for mechanical characterisation of microtumours, cell culture and staining to understand the molecular make-up of microtumours, and microfluidic design and fabrication for the development of advanced tumour-on-chip devices. Using these techniques, you will explore the relationship between the biophysical properties of pancreatic cancer microtumours cultured in a tumour-on-chip device and how these relate to resistance to drug penetration. With this new knowledge, you will investigate novel therapeutic approaches to breaking down these barriers and improving treatment outcomes.

To explore the post further or for any queries you may have, please contact:

, Academic Fellow

Tel: +44 7734669483

Email:

Please note: If you are not a British or Irish citizen, from 1 January 2021 you will require permission to work in the UK. This will normally be in the form of a visa but, if you are an EEA/Swiss citizen and resident in the UK before 31 December 2020, this may be your passport or status under the EU Settlement Scheme.

Location: Leeds - Main Campus
Faculty/Service: Faculty of Engineering & Physical Sciences
School/Institute: School of Physics & Astronomy
Category: Research
Grade: Grade 7
Salary: £33,797 to £40,322 p.a.
Due to funding restrictions an appointment will not be made above £33,797 p.a.
Working Time: 37.5 hours per week
Post Type: Full Time
Contract Type: Fixed Term (2 years (grant funding))
Release Date: Thursday 27 May 2021
Closing Date: Sunday 27 June 2021
Interview Date: To be confirmed
Reference: EPSPA1032


If you apply for this position please say you saw it on Bioloxy

Apply

All Jobs

FACEBOOK
TWITTER
LINKEDIN

Harvard University Academic Positions

Kuwait University Current Faculty Openings

Osaka University Academic Opportunities

Purdue University Job Postings for Faculty Positions

Texas Tech University Faculty Openings

Tsinghua University Job Postings

University of Cambridge Job Openings

University of Geneva Faculty Opportunities

University of New South Wales Job Openings

University of Nottingham Research Positions

University of Oslo Academic Jobs

University of Saskatchewan Faculty Positions

University of Southampton Research Vacancies

University of Tokyo Current Academic Vacancies

University of Toronto Open Faculty Positions