Postdoctoral position at Center for Peptide-Based Antibiotics (University of Copenhagen, Department of Medical Design and Pharmacology)

Postdoctoral position at Center for Peptide-Based Antibiotics A postdoctoral position is available in medicinal chemistry in the area of discovery and studies of novel peptide-based antibiotics. The postdoctoral fellow will be affiliated with Department of Drug Design and Pharmacology. The position is for 2 years (with a possibility of extension) and is available from March 1st, 2019 or upon agreement. Job description The postdoc project involves design and synthesis of novel antisense antimicrobial PNA- conjugates and derivatives. A major task will be to design and synthesize new building blocks that enable exploration of structure-activity relationships in order to optimize antibacterial potency and minimize cytotoxic side effects. Thus, the medicinal chemistry studies comprise identification of safe delivery methods facilitating efficient transport of PNA oligomers conjugates across the bacterial envelope, as well as peptide nucleic acid (PNA) oligomers displaying enhanced affinity to the targeted mRNA. Extensive experience in gram-scale preparative organic synthesis and chromatographic methods is required. A candidate with experience in heterocyclic chemistry with particular emphasis on peptide nucleic acid monomer synthesis as well as relevant analytical methods (NMR, HPLC and MALDI-TOF) will be preferred. The work will be closely integrated with related projects in the research center, and the applicant is expected to possess an outgoing interdisciplinary approach toward collaboration with medicinal chemists as wells as molecular biologists and microbiologists. Scientific environment Center for Peptide-Based Antibiotics (Cepan) offers an ambitious scientific environment, with many different nationalities represented. Cepan is a research center at University of Copenhagen supported by the Novo Nordisk Foundation Challenge program aiming at discovery of novel peptide-based antibiotics targeting resistant Gram-negative bacteria. You can read more at https://cepan.ku.dk/. The work place will be Department of Drug Design and Pharmacology (https://drug.ku.dk/) in Section of Natural Products and Peptides (https://drug.ku.dk/research/npp/). Required qualifications Highly motivated and ambitious candidates are encouraged to apply. Required qualifications: A PhD degree in organic chemistry or medicinal chemistry Relevant scientific experience supported by a strong publication record Proven ability to present and publish research data Excellent English communication skills, both oral and written In all cases, the ability to perform the job will be the primary consideration, and thus the University of Copenhagen wishes to encourage everyone interested in this post to apply, regardless of personal background. Terms of salary and employment: The terms of employment are set according to the Agreement between the Ministry of Finance and The Danish Confederation of Professional Associations or other relevant professional organization. Successful applicants will receive a generous salary from the University of Copenhagen as well as a monthly contribution of 17.1% of the salary paid into a pension fund. Questions For further information about the position, please contact Assoc. Prof. Henrik Franzyk (E-mail: henrik.franzyk@sund.ku.dk) or center leader Prof. Peter E. Nielsen (E-mail: ptrn@sund.ku.dk). Foreign applicants may find the following links useful: www.ism.ku.dk(International Staff Mobility) and www.workingconditions.ku.dk. Application procedure The application must be submitted in English, by clicking on “Apply online” below, and must include the following: Curriculum vitae with a list of publications, a report on previous research undertaken, and the names, addresses and contact details of 3 referees Diplomas – all relevant certificates, including grades An outline of how you could contribute scientifically and intellectually to the research of the center (approximately one A4 page). Please note the applicant will be contacted if the assessment committee requires further documentation. Deadline for application is December 15th, 2018. After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the Appointments Committee. All applicants are then immediately notified whether their application has been passed for assessment by an expert assessment committee. Selected applicants are notified of the composition of the committee and each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself. You can read about the recruitment process at http://employment.ku.dk If you apply for this position please say you saw it on Bioloxy

Postdoctoral position at Center for Peptide-Based Antibiotics

A postdoctoral position is available in medicinal chemistry in the area of discovery and studies of novel peptide-based antibiotics. The postdoctoral fellow will be affiliated with Department of Drug Design and Pharmacology. The position is for 2 years (with a possibility of extension) and is available from March 1st, 2019 or upon agreement.

Job description

The postdoc project involves design and synthesis of novel antisense antimicrobial PNA- conjugates and derivatives. A major task will be to design and synthesize new building blocks that enable exploration of structure-activity relationships in order to optimize antibacterial potency and minimize cytotoxic side effects.

Thus, the medicinal chemistry studies comprise identification of safe delivery methods facilitating efficient transport of PNA oligomers conjugates across the bacterial envelope, as well as peptide nucleic acid (PNA) oligomers displaying enhanced affinity to the targeted mRNA. Extensive experience in gram-scale preparative organic synthesis and chromatographic methods is required. A candidate with experience in heterocyclic chemistry with particular emphasis on peptide nucleic acid monomer synthesis as well as relevant analytical methods (NMR, HPLC and MALDI-TOF) will be preferred.

The work will be closely integrated with related projects in the research center, and the applicant is expected to possess an outgoing interdisciplinary approach toward collaboration with medicinal chemists as wells as molecular biologists and microbiologists.

Scientific environment

Center for Peptide-Based Antibiotics (Cepan) offers an ambitious scientific environment, with many different nationalities represented. Cepan is a research center at University of Copenhagen supported by the Novo Nordisk Foundation Challenge program aiming at discovery of novel peptide-based antibiotics targeting resistant Gram-negative bacteria. You can read more at https://cepan.ku.dk/.

The work place will be Department of Drug Design and Pharmacology (https://drug.ku.dk/) in Section of Natural Products and Peptides (https://drug.ku.dk/research/npp/).

Required qualifications

Highly motivated and ambitious candidates are encouraged to apply.

Required qualifications:

A PhD degree in organic chemistry or medicinal chemistry
Relevant scientific experience supported by a strong publication record
Proven ability to present and publish research data
Excellent English communication skills, both oral and written

In all cases, the ability to perform the job will be the primary consideration, and thus the University of Copenhagen wishes to encourage everyone interested in this post to apply, regardless of personal background.

Terms of salary and employment:

The terms of employment are set according to the Agreement between the Ministry of Finance and The Danish Confederation of Professional Associations or other relevant professional organization. Successful applicants will receive a generous salary from the University of Copenhagen as well as a monthly contribution of 17.1% of the salary paid into a pension fund.

Questions

For further information about the position, please contact Assoc. Prof. Henrik Franzyk (E-mail: henrik.franzyk@sund.ku.dk) or center leader Prof. Peter E. Nielsen (E-mail: ptrn@sund.ku.dk).

Foreign applicants may find the following links useful: www.ism.ku.dk(International Staff Mobility) and www.workingconditions.ku.dk.

Application procedure

The application must be submitted in English, by clicking on “Apply online” below, and must include the following:

Curriculum vitae with a list of publications, a report on previous research undertaken, and the names, addresses and contact details of 3 referees
Diplomas – all relevant certificates, including grades
An outline of how you could contribute scientifically and intellectually to the research of the center (approximately one A4 page).

Please note the applicant will be contacted if the assessment committee requires further documentation.

Deadline for application is December 15th, 2018.

After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the Appointments Committee. All applicants are then immediately notified whether their application has been passed for assessment by an expert assessment committee. Selected applicants are notified of the composition of the committee and each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself. You can read about the recruitment process at http://employment.ku.dk

If you apply for this position please say you saw it on Bioloxy

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