Associate Project Scientist in Biological Chemistry
University of California Los Angeles School of Medicine
United States

Associate Project Scientist

Job #JPF08090
  • Biological Chemistry / David Geffen School Of Medicin / UCLA

Application Window

Open January 3, 2023 through Friday, Feb 3, 2023 at 11:59pm (Pacific Time)

Position description

Applications are sought for a full-time Assistant Project Scientist position. The successful candidate will work as part of an interdisciplinary research team in the laboratory of Dr. Kathrin Plath’s Lab in the UCLA Department of Biological Chemistry. The focus of the Plath Lab is on understanding the gene regulatory mechanisms underlying cellular plasticity, reprgramming and differentiation to open the door to manipulate cell identity and gene expression states and to understand disease processes. Within this context, the Plath lab is studying six fundamental problems: (i) How do long-noncoding (lnc) RNAs build nuclear compartments and regulate chromatin changes during differentiation and reprogramming? This aspect of our work particularly centers on understanding how the X chromosome dosage compensation is regulated by the lncRNA Xist in mouse and human. (ii) Which mechanisms govern reprogramming to induced pluripotency as a means to understand how transcription factors drive cell fate changes and induce new chromatin and gene expression states. (iii) How transcriptional networks and lncRNAs regulate 3D genome organization, and how 3D genome organization in turn influences gene expression, chromatin states, and lncRNA function. (iv) How nutrients that vary with diet can regulate stem cell states and cell fate decisions, particularly those during development, with the ultimate goal to define dietary alterations that enable more accurate models of differentiation in the culture dish or lead to new treatments of pregnancy complications and diseases. (v) Using embryonic stem cells, induced pluripotent stem cells and new embryo models to understand the gene regulatory networks underlying cellular specification during development, implantation and in early pregnancy and to understand how things can go wrong. (vi) Developing new single cell genomics technologies and to apply them to diverse biological model systems to, for instance, understand the difference between the healthy and disease lung.

To address these questions, the Plath lab is using a combination of cell culture, microscopy, biochemistry and mass spectrometry, high-throughput screening, transgenic/knockout mouse models and pluripotent stem cell models, new embryo models, genome engineering, metabolomics, and bulk and single cell genomics approaches, and participate in fruitful collaborations across campuses. The ideal candidate will have an interest in pursuing a project that addresses how X chromosome dosage compensation is regulated during reprogramming, how autophagy contributes to the reprogramming process, and how genetic variation can be exploited to uncover mechanisms underlying cell fate change. The ideal candidate will be motivated to learn and implement a variety of cutting-edge experimental techniques, and will be excited to work with and develop teams within the lab. Projects may include but are not limited to interrogating mechanisms of reprogramming of somatic cells to iPSCs, characterizing the regulation of Xist RNA in the X-inactivation process, and understanding the role of mitophagy regulators in reprogramming to iPSCs.


Basic qualifications (required at time of application)

• PhD in a Biological or Computational Discipline
• Ability to work in a collaborative interdisciplinary environment and experience in establishing new methods and approaches
• Desire to conduct cutting-edge developmental, genomics, molecular and cell biology research
• Experience with the processes of X chromosome dosage compensation, autophagy, reprogramming, cell fate change and the ability to apply genomics approaches

Application Requirements

Document requirements
Reference requirements

Reference not needed.

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Campus Information

As a condition of employment, you will be required to comply with the University of California SARS-CoV-2 (COVID-19) Vaccination Program Policy. All Covered Individuals under the policy must provide proof of Full Vaccination or, if applicable, submit a request for Exception (based on Medical Exemption, Disability, and/or Religious Objection) or Deferral (based on pregnancy) no later than the applicable deadline. New University of California employees must (a) provide proof of receiving at least one dose of a COVID-19 Vaccine no later than 14 calendar days after their first date of employment and provide proof of Full Vaccination no later than eight weeks after their first date of employment; or (b) if applicable, submit a request for Exception or Deferral no later than 14 calendar days after their first date of employment. (Capitalized terms in this paragraph are defined in the policy.) Federal, state, or local public health directives may impose additional requirements.

The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status. For the complete University of California nondiscrimination and affirmative action policy, see: UC Nondiscrimination & Affirmative Action Policy.

Job location

Los Angeles, California

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