Cryo-EM Specialist University of California, San Francisco School Of Medicine - Biochemistry & Biophysics United States

Cryo-EM Specialist



Recruitment Period


Open date: November 5th, 2018
Last review date: Tuesday, Feb 5, 2019 at 11:59pm (Pacific Time)

Applications received after this date will be reviewed by the search committee if the position has not yet been filled.
Final date: Tuesday, May 5, 2020 at 11:59pm (Pacific Time)

Applications will continue to be accepted until this date, but those received after the review date will only be considered if the position has not yet been filled.



Cryo-EM Specialist


We seek to hire 1 ~ 3 cryo-EM specialists, at the levels of Assistant, Associate and Full Specialist level. The Keck Advanced Microscopy Laboratory at UCSF is directed by David Agard, Yifan Cheng and Adam Frost. Our facility currently houses an ThermoFisher FEI Titan Krios with a pre-GIF K2 and a post-GIF K3, a Talos Arctica with a K3 camera, a TF30 Polara and a TF20, both equipped with a K2; a T20 LaB6 equipped with an 8K CCD, an a T12 LaB6 equipped with a 4K UltraScan. The facility is supervised by a manager who oversees microscope maintenance and an IT specialist who oversees data management. The facility has over 100 regular users and is continue training new users.


The specialists will provide support and training for the growing cryo-EM community at UCSF. They will setup microscope for high-quality data acquisition, loading grids for users, and carry out regularly microscope performance test, testing and implementing new data acquisition technologies; In addition, they will participate in various cryo-EM related projects.


In addition to working on cryo-EM related projects, the specialist will provide support and training for the growing cryo-EM community at UCSF. The ideal candidate for this position will be a cryo-EM expert with strong communication skills. If you enjoy teaching, training, and working collaboratively, please apply.


Required Qualifications:
For Assistant Specialist, the candidate must possess at least a master’s degree (or equivalent degree) and is required to have previous hands-on experience (3+ years) in electron microscopy, from operating electron microscope, performing negative stain EM, and experience in operating cryo-EM related sample preparation equipment. Some image processing experience is a plus.


For Associate Specialist, the candidate must possess at least a master’s degree (or equivalent degree) and is required to have previous experience (3+ years) in all aspects of cryo-EM, including operating high-end instruments, such as Titan Krios, Talos Arctica and/or TF30 Polara, various cryo-EM sample preparation techniques, and extensive experience in cryo-EM image processing. Previous experience and knowledge about single particle cryo-EM is required.


For Full specialist, the candidate must possess a terminal degree (or equivalent degree) and is required to have previous experience (5+ years) in managing or working in a multi-user cryo-EM facility, with extensive experience in using and managing electron microscopes, such as identifying problems of various systems, coordinating service, microscope performance test, and extensive experience in cryo-EM data acquisition.


Preferred Qualifications:

  • Post-graduate training in field
  • Independent specialized research
  • Management experience


Please apply online at, with a CV and the contact information for at least two references.


UC San Francisco seeks candidates whose experience, teaching, research, or community service that has prepared them to contribute to our commitment to diversity and excellence. The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status.


Job location

San Francisco, CA



Document requirements

  • Curriculum Vitae - Your most recently updated C.V.

  • Cover Letter (Optional)

  • Statement of Research (Optional)

  • Statement of Teaching (Optional)

  • Statement of Contributions to Diversity (Optional)

  • Misc / Additional (Optional)

Reference requirements
  • 2 required (contact information only)


How to apply

  1. Create an ApplicantID
  2. Provide required information and documents
  3. If any, provide required reference information

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