Faculty Position in Leukemic Stem Cells and Myeloid Leukemia Research
University of Bern Department for BioMedical Research
Switzerland

Master Thesis Position in Leukemic Stem Cells and Myeloid Leukemia Research

The laboratory of "Stem Cells, Leukemia, Aging and Metabolism" (SLAM Lab) at the University Clinic of Hematology & Central Hematology, Department for Bio-Medical Research (DBMR), Inselspital Bern, Switzerland is looking for highly motivated master students to contribute to the ongoing multidisciplinary research projects in leukemia. The major focus of the lab is to explore leukemic stem cell dependencies and vulnerabilities using transgenic mouse models and primary patient samples from leukemia patients.
 
Your profile
 
Highly motivated Master's student with a strong passion towards fundamental and translational cancer research. Any relevant hands-on laboratory experience would be a plus but not obligatory.
 
We offer you
 
The student will be guided through an interdisciplinary and clearly defined research project in a young and dynamic environment. The proposed project will investigate the therapeutic relevance of targeting selected altered metabolic pathways in myeloid leukemias and other hematological cancers by using:
• In vitro cell and molecular biology techniques such as cloning, CRISPR/Cas9 genome editing, stem cell cultures, RT-qPCR, flow cytometry, harmacological inhibition and metabolic flux assays.
• Ex-vivo cellular and metabolic assays on transgenic mouse models of myeloid leukemia.
 
Application
 
Please submit your application in a single PDF file including cover letter (one page max) specifying your research interests and why you are interested in joining our lab, CV (two pages max) and copies of Bachelor and/or Master's degree to: tata.nageswararao@dbmr.unibe.ch with desired start date!!!
The duration of master thesis is 6-12 months. The starting date is negotiable.

Relevant reading

1). Rao TN et al., Metabolic alterations in JAK2 mutant hematopoietic cells represent therapeutic vulnerabilities for myeloproliferative neoplasms. Blood. 2019.
2). Rao TN et al., Attenuation of PKC activity enhances metabolic activity and regenerative capacity of blood progenitors. The EMBO Journal, 2018.

University Clinic of Hematology, Dept. of Bio-Medical Research (DBMR)
Inselspital Bern, University of Bern,
Murtenstrasse 40, 3008, Bern, Switzerland
tata.nageswararao@dbmr.unibe.ch Tel: +41 (0) 31 6641476


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