PhD Candidate in Biology (Masaryk University)

About this position: We're excited to announce an open PhD student position in Robert Vacha's Research Group! Membrane fusion is an essential biological process that plays a crucial role in neurotransmission, intracellular trafficking, and immune responses. Despite its fundamental biological role and potential application in drug delivery, the molecular understanding of membrane fusion and its control remain elusive. This ERC-funded project aims to the design of novel peptides and peptide aggregates able to induce spontaneous fusion. The peptides have been selected based on their biocompatibility and our exceptional experience with membrane-active peptides, including the design of de novo sequences based on the elucidated mechanism. The first step will be to develop a computational approach to determine the critical peptide properties required to destabilize or stabilize key fusion states: membrane stalk, hemifusion diaphragm, and fusion pore. These findings will then be used to de novo design peptide sequences where the fusogenic role of each amino acid is known, providing the key advantage for customization for vaccination and drug delivery. The computational results will be verified by fluorescence and electron microscopy. The ideal candidate profile: Must-have: MSc or equivalent degree in computational simulations and related fields Theoretical knowledge of Molecular Dynamics and/or Monte Carlo Good English language – spoken and written Nice-to-have: Work experience in simulations with proteins/membranes and their analysis Good communication and interpersonal skills Motivation and a collaborative mindset What we provide to you: Open access to CEITEC MU core facilities with state-of-the-art equipment and experienced staff Full-time contract An attractive salary (ERC funded position) Flexible working hours Support for further education and professional development Benefits package: 6 weeks of paid holiday, medical insurance, financial contribution to meal and kindergarten/pension scheme, Multisport card, mental health care, sports lessons directly at the campus Kindergarten Elánek in Campus Support in these areas: Welcome Office service before and after arrival Grant Office support Postdoc Peer Committee CEITEC events – workshops, conferences, lectures, training, family gathering etc. How to apply? Application deadline: 31.12.2024 Start date: 1.1.2025 or by negotiation Applications, including a CV, motivation letter, list of publications, and contacts for at least two references should be sent an e-application HERE. Any troubles with the e-application, please contact Petra Linhartova (petra.linhartova@ceitec.muni.cz) If you apply for this position please say you saw it on Bioloxy

About this position:

We're excited to announce an open PhD student position in Robert Vacha's Research Group!

Membrane fusion is an essential biological process that plays a crucial role in neurotransmission, intracellular trafficking, and immune responses. Despite its fundamental biological role and potential application in drug delivery, the molecular understanding of membrane fusion and its control remain elusive.

This ERC-funded project aims to the design of novel peptides and peptide aggregates able to induce spontaneous fusion. The peptides have been selected based on their biocompatibility and our exceptional experience with membrane-active peptides, including the design of de novo sequences based on the elucidated mechanism. The first step will be to develop a computational approach to determine the critical peptide properties required to destabilize or stabilize key fusion states: membrane stalk, hemifusion diaphragm, and fusion pore. These findings will then be used to de novo design peptide sequences where the fusogenic role of each amino acid is known, providing the key advantage for customization for vaccination and drug delivery. The computational results will be verified by fluorescence and electron microscopy.

The ideal candidate profile:

Must-have:

MSc or equivalent degree in computational simulations and related fields
Theoretical knowledge of Molecular Dynamics and/or Monte Carlo
Good English language – spoken and written

Nice-to-have:

Work experience in simulations with proteins/membranes and their analysis
Good communication and interpersonal skills
Motivation and a collaborative mindset

What we provide to you:

Open access to CEITEC MU core facilities with state-of-the-art equipment and experienced staff
Full-time contract
An attractive salary (ERC funded position)
Flexible working hours
Support for further education and professional development
Benefits package: 6 weeks of paid holiday, medical insurance, financial contribution to meal and kindergarten/pension scheme, Multisport card, mental health care, sports lessons directly at the campus
Kindergarten Elánek in Campus
Support in these areas:
- Welcome Office service before and after arrival
- Grant Office support
- Postdoc Peer Committee
- CEITEC events – workshops, conferences, lectures, training, family gathering etc.