PhD Fellowship in Computational Biology
University of Copenhagen
Denmark

PhD Fellowship in Computational Biology

We are offering a PhD fellowship in Computational Biology commencing 1 September, 2020. 

Our group and research

The Weischenfeldt lab is working on delineating the mutational mechanisms and clonal evolution of cancer. We use a wide range of computational and experimental approaches including WGS, single-cell, and long-read sequencing together with chromatin conformation techniques to understand how cancers mutate and evolve, which we are applying to cancer patient material in close collaboration with clinical colleagues at the hospital.

Project description

The aim of the PhD project is to use computational genomics approaches on whole-genome sequencing material to study tumor evolution from patient-derived tumor biopsy samples. The project involves studying patterns of clonal evolution with a focus on complex rearrangements in cancers.

The project will involve analysis of several layers of comics data integration and can be divided into three sub-projects:

  1. Develop and apply methods to reconstruct clonal evolution from primary and relapse tumor material
  2. Identify recurrent patterns of selection
  3. Characterise processes leading to treatment resistance and identify potential targetable mutations.
The successful candidates will be joining a larger team of cross-disciplinary computational, basic and clinical cancer researchers, and will be exposed to a range of methodologies and approaches. The PhD student will also have a lot of possibilities to develop own ideas.

Starting date: 1 September 2020 or after agreement.

Duration: 3 years as a PhD student
Principal supervisor is group leader, assoc prof Joachim Weischenfeldt, BRIC and Rigshospitalet, joachim.weischenfeldt@bric.ku.dk, Phone: +453545 6040
Your job

Your key tasks as a PhD student at SUND are:
  • Carry through an independent research project under supervision 
  • Complete PhD courses or other equivalent education corresponding to approx. 30 ECTS points 
  • Participate in active research environments including a stay at another research team 
  • Obtain experience with teaching or other types of dissemination related to your PhD project 
  • Teach and disseminate your knowledge Write a PhD thesis on the grounds of your project 
Profile

We are looking for highly motivated and enthusiastic canddiate with the following competencies and experience:

Essential experience and skills:
  • You have a Master’s degree or similar in computational biology, bioinformatics or related areas
  • Experience with NGS data
  • Good English skills written and spoken

Desirable experience and skills:

  • Experience with tumour evolution
  • Professional qualifications relevant to the PhD project
  • The grade point average achieved
  • Previous publications
  • Relevant work experience 
  • Curious mind-set with a strong interest in computational biology 

Place of employment

The place of employment is at BRIC, University of Copenhagen. We offer creative and stimulating working conditions in dynamic and international research environment. Our research facilities include modern laboratories and access to HPC.
Please read more about our research at
https://www.bric.ku.dk/Research/weischenfeldt-group/

Terms of employment

The employment as PhD fellow is full time and for 3 years.

It is conditioned upon the applicant’s successful enrolment as a PhD student at the Graduate School at the Faculty of Health and Medical Sciences, University of Copenhagen. This requires submission and acceptance of an application for the specific project formulated by the applicant during an initial three-month employment as a research assistant.

The PhD study must be completed in accordance with The Ministerial Order on the PhD programme (2013) and the Faculty’s rules on achieving the degree. Salary, pension and terms of employment are in accordance with the agreement between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State. Depending on seniority, the monthly salary begins around 26.755 DKK /approx. 3.567 EUR (April 2018-level) plus pension.

Questions

For further information please contact Joachim Weischenfeldt, joachim.weischenfeldt@bric.ku.dk

Foreign applicants may find this link useful: www.ism.ku.dk (International Staff Mobility).

Application procedure

Your application must be submitted electronically by clicking ‘Apply now’ below. The application must include the following documents in PDF format: 

1. Motivated letter of application (max. one page)

2. CV incl. education, experience, language skills and other skills relevant for the position

3. Master of Science diploma and transcript of records. If not completed, a certified/signed copy of a recent transcript of records or a written statement from the institution or supervisor will do

4. Publication list (if possible)

Application deadline: 10 July 2020, 23.59pm CET

We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.

The further process

After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor.

The assessor makes a non-prioritized assessment of the academic qualifications and experience with respect to the above-mentioned area of research, techniques, skills and other requirements listed in the advertisement.

Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.

You can read about the recruitment process at http://employment.ku.dk/faculty/recruitment-process/

The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.

Interviews are expected to be held in week 32 and 33.

University of Copenhagen wish to reflect the diversity of society and welcome applications from all qualified candidates regardless of age, disability, gender, nationality, race, religion or sexual orientation. Appointment will be based on merit alone.

APPLY NOW

Part of the International Alliance of Research Universities (IARU), and among Europe’s top-ranking universities, the University of Copenhagen promotes research and teaching of the highest international standard. Rich in tradition and modern in outlook, the University gives students and staff the opportunity to cultivate their talent in an ambitious and informal environment. An effective organisation – with good working conditions and a collaborative work culture – creates the ideal framework for a successful academic career.

Info

Application deadline: 10-07-2020
Employment start: 01-09-2020
Working hours: Full time
Department/Location: BRIC


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