PhD position in Biology The Dulin lab has to offer one NWO funded PhD position (4 years) to start as soon as possible in the field of single-molecule biophysics to SARS-CoV-2 replication-transcription regulation. Please apply at Vrije Universiteit Amsterdam. Job descriptionThe successful candidates will investigate how replication and transcription in coronaviruses are regulated by viral proteins associating with the polymerase and the viral genome sequence. To this end, she/he will use state-of-the-art single molecule techniques. Within the lab, the successful candidate will design, perform experiments, and develop new computational analysis tools to analyze her/his data. RequirementsWe are seeking for
The candidate will successfully develop and combine different expertise in physics, biology and software programming to establish new single-molecule assays and investigate how the coronavirus RNA synthesis machinery assembles and is regulated during viral RNA replication and transcription. Proficiency in English (both speaking and writing) is required. What are we offering?A challenging position in a socially involved organization. The salary will be in accordance with university regulations for academic personnel and amounts €2,541 (PhD) per month during the first year and increases to €3,247 (PhD) per month during the fourth year, based on a full-time employment. The job profile is based on the university job ranking system and is vacant for at least 0.8 FTE.
About Vrije Universiteit AmsterdamThe ambition of Vrije Universiteit Amsterdam is clear: to contribute to a better world through outstanding education and ground-breaking research. We strive to be a university where personal development and commitment to society play a leading role. A university where people from different disciplines and backgrounds collaborate to achieve innovations and to generate new knowledge. Our teaching and research encompass the entire spectrum of academic endeavor – from the humanities, the social sciences and the natural sciences through to the life sciences and the medical sciences. EnvironmentThe Dulin lab is located at VU Amsterdam (https://daviddulinlab.com/), one of the best universities in the Netherlands, and a leading scientific institution in biophysics located in the vibrant and international city of Amsterdam. Our team is an inclusive and diverse environment, welcoming excellent students from all backgrounds. We are embedded within the Physics of Living System Section of the Physics Department of VU, together with several other biophysics lab, constituting a uniquely thriving environment in physics of life, specifically in single-molecule biophysics. The Dulin lab has a strong expertise in investigating protein-RNA interactions, such as viral replication machinery of viruses using single molecule biophysics techniques, with several breakthrough studies on SARS-CoV-2 genome replication and antiviral drugs evaluation (Bera et al., Cell Reports 2021; Seifert et al., eLife 2021). The successful candidate will join an enthusiastic and international team of biophysicists and biochemists ready to tackle highly challenging problems related to antiviral drug discoveries. She/he will have access to a large variety of cutting-edge assays in single molecule force and fluorescence spectroscopy techniques (e.g. magnetic and optical tweezers, TIRF microscope…), and a molecular biology facility to perform their research. She/he will also benefit from the support of an experienced staff in molecular biology, biochemistry and data analysis. She/he will have the opportunity to learn from the best scientists in the field, publish in high-impact journals and present their work at international conferences. Vacancy questions
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