PhD Position in Biomedicine (University of Luxemburg)

About the LCSB The University of Luxembourg is an international research university with a distinctly multilingual and interdisciplinary character. The Luxembourg Centre for Systems Biomedicine (LCSB) is an interdisciplinary research centre of the University of Luxembourg. We conduct fundamental and translational research in the field of Systems Biology and Biomedicine – in the lab, in the clinic, and in silico. We focus on neurodegenerative processes and are especially interested in Alzheimer’s and Parkinson’s disease and their contributing factors. The LCSB recruits talented scientists from various disciplines: computer scientists, mathematicians, biologists, chemists, engineers, physicists and clinicians. Currently, researchers from more than 50 countries work at the LCSB. We excel because we are truly interdisciplinary, and together we contribute to science and society. Your Role Multi-omics data integration and workflow improvement Development and application of machine learning-based algorithms for the identification of antibiotics-associated proteins and antimicrobial peptides Perform and support experimental studies across the METAMIC project, including notably metagenomic sequencing of field study samples (from clinical or environmental use cases) Application of improved workflows in field studies These tasks will be carried out within the Marie Skłodowska-Curie Doctoral network METAMIC 3 - Metaproteome-based leveraged microbiome management in the context of One Health, funded by the European Commission under the Horizon Europe framework programme (Grant Agreement number 101225682). The METAMIC 3 project will embed Doctoral Candidates (DCs) in a unique training environment to advance microbiome science through metaproteomics. The program addresses One Health challenges by integrating research on microbial mechanisms, microbiome dynamics in various ecosystems, and translational applications in clinical and biotech fields. DCs will benefit from expertise across molecular biology, bioinformatics, clinical research, and environmental science, supported by collaborations among academia, industry, and public sector partners. For further details about the overall research project, please contact paul.wilmes@uni.lu. Your Profile Master’s, Diploma or equivalent degree in bioinformatics, computational biology, systems biology, biology, or similar Experience in structural and functional protein annotation (sequence homology- or protein structure-based) Familiarity with UNIX/LINUX-based operating systems and shared compute infrastructure Proficiency in Python, R, or similar languages for data analysis Proficiency in scientific English (written and spoken) is a must; German and/or French is an advantage Willingness to spend several months at other institutions abroad. The project envisages the following secondments: 3 months at ISAS with co-supervisor R. Heyer to exchange on data formats and to be trained on the new version of the MetaProteomeAnalyzer Software 3 months at UGENT with B. Mesuere to integrate the developed tools 1 month at the Health Inspectorate of the Luxembourg Health Directorate to gain insights into public health objectives and activities in the context of national health strategies Eligibility Criteria Academic Qualification: Must hold a relevant Master’s degree or equivalent and obtained it by the DC start date Must not already hold a doctoral degree (Ph.D.) Mobility Requirement: Must not have resided or carried out main activity (work, studies, etc.) in Luxembourg for more than 12 months in the 3 years immediately prior to recruitment We Offer Multilingual and international character. Modern institution with a personal atmosphere. Staff coming from 90 countries. Member of the “University of the Greater Region” (UniGR) A modern and dynamic university with high-quality equipment and close ties to the business world and the Luxembourg labour market A unique urban site with excellent infrastructure Strong cooperation with European institutions, innovative companies, the Financial Centre, and non-academic partners (ministries, local governments, associations, NGOs, etc.) How to Apply Applications should include: Curriculum Vitae Cover letter Early application is highly encouraged, as applications will be processed upon reception. Please apply ONLINE formally through the HR system. Applications by email will not be considered. All qualified individuals are encouraged to apply. The University of Luxembourg promotes an inclusive culture and encourages applications from individuals of all backgrounds, upholding equality and respect for employees and students. General Information Contract Type: Fixed Term Contract (36 Months) Work Hours: Full Time (40 hours/week) Location: Belval Campus Internal Title: Doctoral Researcher Job Reference: UOL07674 The yearly gross salary for every PhD at the University of Luxembourg is EUR 41,976 (full time). If you apply for this position please say you saw it on Bioloxy

About the LCSB

The University of Luxembourg is an international research university with a distinctly multilingual and interdisciplinary character.

The Luxembourg Centre for Systems Biomedicine (LCSB) is an interdisciplinary research centre of the University of Luxembourg. We conduct fundamental and translational research in the field of Systems Biology and Biomedicine – in the lab, in the clinic, and in silico.

We focus on neurodegenerative processes and are especially interested in Alzheimer’s and Parkinson’s disease and their contributing factors. The LCSB recruits talented scientists from various disciplines: computer scientists, mathematicians, biologists, chemists, engineers, physicists and clinicians. Currently, researchers from more than 50 countries work at the LCSB. We excel because we are truly interdisciplinary, and together we contribute to science and society.

Your Role

Multi-omics data integration and workflow improvement
Development and application of machine learning-based algorithms for the identification of antibiotics-associated proteins and antimicrobial peptides
Perform and support experimental studies across the METAMIC project, including notably metagenomic sequencing of field study samples (from clinical or environmental use cases)
Application of improved workflows in field studies

These tasks will be carried out within the Marie Skłodowska-Curie Doctoral network METAMIC 3 - Metaproteome-based leveraged microbiome management in the context of One Health, funded by the European Commission under the Horizon Europe framework programme (Grant Agreement number 101225682).

The METAMIC 3 project will embed Doctoral Candidates (DCs) in a unique training environment to advance microbiome science through metaproteomics. The program addresses One Health challenges by integrating research on microbial mechanisms, microbiome dynamics in various ecosystems, and translational applications in clinical and biotech fields.

DCs will benefit from expertise across molecular biology, bioinformatics, clinical research, and environmental science, supported by collaborations among academia, industry, and public sector partners.

For further details about the overall research project, please contact paul.wilmes@uni.lu.

Your Profile

Master’s, Diploma or equivalent degree in bioinformatics, computational biology, systems biology, biology, or similar
Experience in structural and functional protein annotation (sequence homology- or protein structure-based)
Familiarity with UNIX/LINUX-based operating systems and shared compute infrastructure
Proficiency in Python, R, or similar languages for data analysis
Proficiency in scientific English (written and spoken) is a must; German and/or French is an advantage
Willingness to spend several months at other institutions abroad. The project envisages the following secondments:
- 3 months at ISAS with co-supervisor R. Heyer to exchange on data formats and to be trained on the new version of the MetaProteomeAnalyzer Software
- 3 months at UGENT with B. Mesuere to integrate the developed tools
- 1 month at the Health Inspectorate of the Luxembourg Health Directorate to gain insights into public health objectives and activities in the context of national health strategies

Eligibility Criteria

Academic Qualification: Must hold a relevant Master’s degree or equivalent and obtained it by the DC start date
Must not already hold a doctoral degree (Ph.D.)
Mobility Requirement: Must not have resided or carried out main activity (work, studies, etc.) in Luxembourg for more than 12 months in the 3 years immediately prior to recruitment

We Offer

Multilingual and international character. Modern institution with a personal atmosphere. Staff coming from 90 countries. Member of the “University of the Greater Region” (UniGR)
A modern and dynamic university with high-quality equipment and close ties to the business world and the Luxembourg labour market
A unique urban site with excellent infrastructure
Strong cooperation with European institutions, innovative companies, the Financial Centre, and non-academic partners (ministries, local governments, associations, NGOs, etc.)

How to Apply

Applications should include:

Curriculum Vitae
Cover letter

Early application is highly encouraged, as applications will be processed upon reception. Please apply ONLINE formally through the HR system. Applications by email will not be considered.

All qualified individuals are encouraged to apply. The University of Luxembourg promotes an inclusive culture and encourages applications from individuals of all backgrounds, upholding equality and respect for employees and students.