Organisational Unit: The Laboratory of Experimental Cardiology: The Laboratory of Experimental Cardiology is part of the cluster ‘Cardiac structure and function’ investigating cardiac structural, contractile and electrical remodeling processes during cardiovascular disease. This involves investigating from the cellular to the organ level, molecular mechanisms, left and right ventricular mechanics and impact of different interventions and anaesthetics. The laboratory is highly international consisting of post-doctoral scientists, PhD students and technicians. The laboratory is equipped with the wide range of expertise and skills required to manipulate and probe the transcriptome/epigenome (and the mechanisms governing functions and phenotype of the heart and cardiac myocyte fate choices). These resources span across mouse and large animal models of cardiac disease, GM mice, iPS cells, Single cell sequencing (10x and plate methods) RNA-Seq, ChiP-Seq, DNA (hydroxy)methylation analysis and analysis of excitation contraction coupling. You will receive extensive training and support in these areas. Through our excellent local and international collaborators and core facilities, you will have access to additional expertise and tools. The Department: The Department is situated in the Biomedical Campus of KU Leuven. It has the entire range of competences from basic science, over pre-clinical modeling to applied clinical and epidemiological research, taking a systems approach to the complexity of cardiovascular disorders. The University: KU Leuven offers a stimulating environment for international students and support for junior scientists to achieve their ambitions and in career development.
ProjectCell-Cell interactions in atrial myopathy and atrial fibrillation: We are recruiting a motivated graduate student to join on a new exciting collaborative multi-centre study to identify the cell-cell interactions that drive atrial remodelling during disease and ageing that leads to atrial fibrillation. The study will involve analysis of patient samples, preclinical models of AF as well as cell models. We will employ 10x sequencing approaches and in situ analysis to identify cell composition and cell state changes as well as changes in cells communication.Validation of findings will be in animal models and by mathematical modelling.Post-holders will receive training and gain experience in collaborative translational research and will be given opportunities to develop their skills at through interactions and visits/extended stays to partner laboratories. Suitable candidates that focus on wet or dry lab aspects of this project are invited to apply. Candidates with experience and/or knowledge in the areas of cardiovascular biology, next generation sequencing approaches including single cell analysis, bioinformatics and bioimaging are particularly encouraged to apply although enthusiasm and dedication is most sought after. Responsibilities:
ProfileYou are motivated, have an enquiring mind and are excited by science. OfferA fully funded 4 year PhD position. Interested?Please send your CV, motivation letter and 2 recommendation letters toProf. Dr. H. Llewelyn Roderick, Email: (Llewelyn.roderick@kuleuven.be). Please also applyvia the online portal of KU Leuven. You can apply for this job no later than March 12, 2021 via the
KU Leuven seeks to foster an environment where all talents can flourish, regardless of gender, age, cultural background, nationality or impairments. If you have any questions relating to accessibility or support, please contact us at diversiteit.HR@kuleuven.be.
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