The role of lipids in mediating the spatiotemporal coordination of cell division.PhD position in plant membrane biology09.02.2023, Wissenschaftliches Personal Your research and responsibilities: In plants, patterning by cell division relies on division plane establishment, on the biogenesis of a membrane compartment called the cell plate, and on cell plate insertion at the division site. The processes of cell plate guidance and insertion are poorly understood. Lipids are increasingly recognized as important membrane landmarks, but whether specific lipids mark the division site has yet to be investigated. Your activities will address the following questions: i) how are lipids sorted at the expanding cell plate or division site? ii) does lipid sorting require a Rab Guanine nucleotide Exchange Factor? iii) conversely, do lipid landmarks regulate Guanine nucleotide Exchange Factor function? Your results will considerably further our understanding of the establishment, recognition and function of membrane micro-domains. This is a collaborative, interdisciplinary project. In cutting-edge facilities, the project spans a broad range techniques: lipid biosensors, lipid click-chemistry, inducible depletion of lipids by optogenetics, super-resolution microscopy, targeted immuno-isolation of membrane complexes, proteomics and lipidomics. Your qualifications: Hinweis zum Datenschutz: Kontakt: farhah.assaad@tum.de
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