PhD Position in Stem Cell and Developmental Epigenetics
Catholic University of Leuven
Belgium

 
Embryonic cells in the earliest stages of development can generate the entire fetal body, a feature known as pluripotency. In mammals, this process involves dynamic changes in the removal and addition of methyl groups at specific positions in DNA. Changes in DNA methylation regulate gene expression and phenotype without altering the DNA sequence, constituting an important part of “epigenetics” research. The TET DNA dioxygenases erase DNA methylation by reiterative oxidation of 5-methylcytosine via 5-hydroxymethylcytosine and have major roles as epigenetic regulators in development and disease. As co-discoverer of the TET family, Prof. Kian Koh at KU Leuven studies the regulation of TET in pluripotency and early embryonic differentiation. Recent work by the group has opened new lines of investigation of TET1’s interesting roles in both embryonic and extra-embryonic lineages of the early post-implantation mouse embryo: www.news-medical.net/news/20170518/KU-Leuven-researchers-identify-vital-role-of-TET1-protein-in-earliest-stages-of-embryonic-development.aspx.

Project

Using transgenic mouse strains generated in the laboratory, projects are available to investigate distinct epigenetic mechanisms regulating chromatin accessibility, gene expression and DNA methylation in lineage-specific embryonic versus extra-embryonic development, neurulation and cell fate reprogramming. The candidate will complement in vivo work conducted in mice with in vitro studies using stem cell cultures, to understand how gene expression are controlled by TET proteins in possibly different ways in different cell lineages.  Ultimately, the studies will provide important information of how proper regulation of DNA methylation in early development can tip the balance between health and disease later in life, with a focus on aging-related neurological disorders, neurodegeneration and cancer.



Selected Publications:
* Khoueiry R, Sohni A, Thienpont B, Luo XL, Vande Velde J, Bartoccetti M, Boeck B, Zwijsen A, Rao A, Lambrechts D, Koh KP (2017). Lineage-specific functions of TET1 in the post-implantation mouse embryo. Nature Genetics 49, 1061-1072.
* Koh KP, Yabuuchi A, Rao S, Huang Y, Cunniff K, Nardone J, Laiho A, Tahiliani M, Sommer CA, Mostoslavsky G, Lahesmaa R, Orkin SH, Rodig SJ, Daley GQ, Rao A (2011). Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells. Cell Stem Cell 8, 200-213.


Profile

• You have a Bachelor Honors or Master’s degree from one of the countries of the EU, the EER, the UK or Switzerland, in molecular and cellular biology, biochemistry or a related biomedical field with excellent grades.
• You have good command of written and spoken English and are motivated to read and write manuscripts and research proposals.
• You have a passion for science and can thrive in an ambitious and highly interdisciplinary environment.


Offer

You will be paid salary and benefits based on KU Leuven employment guidelines. Scholarship is available for 4 years upon satisfactory evaluation during the first year. The successful candidate must also be competitive for Belgium national fellowships.


Interested?

For more information please contact Christina Vochten: christina.vochten@kuleuven.be.


You can apply for this job no later than January 31, 2020 via the
KU Leuven seeks to foster an environment where all talents can flourish, regardless of gender, age, cultural background, nationality or impairments. If you have any questions relating to accessibility or support, please contact us at diversiteit.HR@kuleuven.be.
    • Employment percentage: Voltijds
    • Location: Leuven
    • Apply before: January 31, 2020
    • Tags: Ontwikkeling en Regeneratie
    • Download: file


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