The Beets lab (Neural Signaling and Circuit Plasticity group) at the Biology Department of KU Leuven (www.kuleuven.be) is seeking a motivated and creative postdoctoral scientist to study the temporal dynamics of neuropeptide signaling networks in C. elegans. Our research addresses fundamental questions on how neuromodulatory networks mediate experience-dependent plasticity in nervous systems. Ultimately, this requires an understanding of when and how specific neuromodulatory pathways act within the context of neuronal circuitry to encode contextual information and reprogram motor output. To achieve such a reductionist understanding of neuromodulation, we are using the genetically tractable model organism C. elegans that has a compact and well-defined nervous system. Our research group is part of the Animal Physiology and Neurobiology division at KU Leuven (https://bio.kuleuven.be/df) and is located on a beautiful campus in historic Leuven, proclaimed the European Capital of Innovation 2020. We are also affiliated with the Leuven Brain Institute (https://gbiomed.kuleuven.be/english/LBI) at the Biomedical Sciences Campus.
ResponsibilitiesNeuromodulatory signals, such as neuropeptides, are important in fine-tuning behaviors depending on internal state and environmental context. While these functions have been established for several neuropeptides, understanding the fundamental principles of neuromodulation requires insight into when and how specific neuropeptide pathways operate within the context of neuronal circuitry. Such a reductionist understanding of neuromodulation presents several challengers. Neuropeptides are diverse, broadly expressed, and have combinatorial actions that can be challenging to dissect, especially in numerically complex brains. Moreover, neuropeptide circuits often communicate through wireless non-synaptic signaling and can be sculpted by experience. In simpler genetically tractable organisms such as the nematode C. elegans, understanding the temporal dynamics of neuropeptide signaling, however, is an achievable goal. We are using the nematode C. elegans, whose neural connectome has been completely mapped, to discover fundamental principles of neuropeptidergic modulation. Using a system-wide approach, we are mapping the neuropeptide signaling network in C. elegans that consists of a dense and evolutionarily conserved network of neuropeptide-receptor interactions. As a model, C. elegans has two main advantages to map neuropeptide connectivity brain-wide: The anatomic simplicity of its nervous system facilitates such a comprehensive analysis, and the neuropeptide network can be compared with the already established synaptic connectome. Using a broad range of approaches, including optogenetics, tracking-based behavioral analysis, cell-type specific RNAseq and molecular genetics, we are investigating when and where neuropeptides act within this network to understand how they control behavioral states. In particular, we have focused on microcircuits involved in aversive learning and homeostasis that we found to be regulated by specific and temporally-defined neuropeptide signaling interactions. We are also developing tools that allow visualizing neuropeptide signaling in vivo to further dissect these temporal dynamics.
In your role as postdoc, you will have the opportunity to shape and lead research projects to uncover mechanisms by which neuropeptidergic circuits regulate behavior. You need to be able to organize and troubleshoot your work independently, document it thoroughly and communicate results and experience with the team in a transparent and professional manner. In addition, you must have good communication skills and a collaborative spirit. You provide advice and guidance to bachelor, master and PhD students where applicable.
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Interested?Candidates can apply by submitting their CV and motivation letter via the online application tool. Please also include the names and contact details of three senior researchers that are willing to write a letter of recommendation upon request. For more information please contact Prof. dr. Isabel Beets, tel.: +32 16 37 36 97, mail: isabel.beets@kuleuven.be. You can apply for this job no later than January 31, 2021 via the
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