PhD Student in Biology
Ludwig Maximilians University of Munich
Germany

PhD Student (m/f/d)

Einrichtung: Fakultät für Biologie
Besetzungsdatum: At the next possible date
Ende der Bewerbungsfrist: 31.03.2020
Entgeltgruppe: E13
Befristung: 3 years


Es besteht grundsätzlich die Möglichkeit der Teilzeitbeschäftigung. (Stundenzahl: 65%)

Die Ludwig-Maximilians-Universität München (LMU) ist eine der renommiertesten und größten Universitäten Deutschlands.

Aufgaben

Applications are invited for a PhD positions in the group of Dr. Sebastian Bultmann (Faculty of Biology, Humanbiology and Bioimaging, Ludwig-Maximilians-Universität München) to investigate the function of the epigenetic reader/writer and E3 ubiquitin ligase UHRF1, a key player in DNA methylation maintenance.

DNA methylation plays a central role in the control of gene expression and in maintaining genomic stability. Anomalies in DNA methylation are linked to many inherited (e.g. ICF or Prader-Willi syndromes) and sporadic (e.g. dementia and cancer) human diseases. During each round of DNA replication the genome becomes hemi-methylated, and it is converted back to its fully methylated status by the maintenance methyltransferase DNMT1. DNA methylation by DNMT1 critically depends on ubiquitylation of histone H3 by UHRF1.

The project is an international collaboration between the groups of Dr. Till Bartke (Institute of Functional Epigenetics, Helmholtz Zentrum München), Dr. Pierre- Antoine Defossez (CNRS/Université Diderot in Paris, France) and the Bultmann group. We want to investigate how UHRF1 ubiquitylates precisely the lysine residues in histone H3 that are recognized by DNMT1, and we want to identify new parts of UHRF1 that are required for its function. The project in the Bultmann group plans to use genome engineering techniques and genetic models in mouse embryonic stem cells (ES cells) in order to perform high-throughput screens for UHRF1 mutants that are defective in DNA methylation maintenance.

Anforderungen

We are looking for candidates with experience in cell biological, genome engineering, and high-throughput sequencing methods (project 2), who have a strong interest in applying cutting edge technologies to gain an integrated understanding of the molecular functions of UHRF1, an essential regulator of DNA methylation with clear relevance to human health. Candidates should have a M.Sc. (or equivalent) in Biochemistry, Molecular, Structural, or Cell Biology. We particularly encourage applications from highly motivated, open-minded individuals who are able to work in a team.

Wir bieten Ihnen eine interessante und verantwortungsvolle Tätigkeit mit guten Weiterbildungs- und Entwicklungsmöglichkeiten. Schwerbehinderte Personen werden bei ansonsten im Wesentlichen gleicher Eignung bevorzugt. Die Bewerbung von Frauen wird begrüßt.

Bewerbungsadresse

For further details applicants should contact Dr. Sebastian Bultmann (bultmann@biologie.uni-muenchen.de). Please send a CV, a brief statement of interest, and contact details for two referees.
E-Mail: bultmann@biologie.uni-muenchen.de

Ansprechpartner/in

Dr. Sebastian Bultmann


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