Post Doc in Structural Characterization and Biophysical Analysis of Periplasmic Protein Quality Control Factors
University of Gothenburg Department of Chemistry and Molecular Biology
Sweden

Postdoc in Structural Characterization and Biophysical Analysis of Periplasmic Protein Quality Control Factors

Ref PAR 2021/111

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The University of Gothenburg tackles society’s challenges with diverse knowledge. 49 000 students and 6 400 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract scientists and students from around the world. With new knowledge and new perspectives, the University contributes to a better future.

Research and graduate education at the department of chemistry and molecular biology comprises a wide scientific field from the atomic and molecular levels all the way through cells to intact organisms. Much of the phenomena studied here impact on our natural environment and living systems. We participate in undergraduate programs in chemistry, molecular biology, medicinal chemistry, biology, marine sciences, and pharmacy. The group of Björn Burmann uses state of the art NMR-spectroscopy to study large molecular complexes underlying basic cellular functions at the atomic level in combination with other structural biology methods and biophysical characterization. Björn Burmann’s group investigates macromolecular protein machines underlying essential cellular functions, e.g. protein quality control and their effect on misfolding- and aggregation-prone proteins underlying several different diseases, through biophysical and structural biology approaches e.g. high-resolution Nuclear Magnetic Resonance (NMR). 

Job assignments

Structural characterization and in-depth biophysical analysis of the chaperone governed membrane protein folding. Integral membrane proteins rely on an intricate chaperone network transporting them to their destination, support their correct folding and possibly are also involved in the turn-over of this class of proteins. Based on high-resolution NMR-spectroscopy techniques established for the study of high-molecular weight chaperone complexes a detailed characterization of integral membrane proteins as well as soluble proteins residing in the bacterial periplasm is planned employing recently introduced in-situ techniques.To achieve this goal, you will use a plethora of techniques ranging from basic biochemistry to advanced structural biology methods (not restricted to NMR-spectroscopy only, as it is planned to also apply X-Ray crystallography or cryo-electron microscopy whenever indicated by our data) and biophysical characterization. Methods in microbiology, molecular biology, bioinformatics and biochemistry will also be used. We are looking for a colleague, that is highly motivated, scientifically independent and creative, and capable of contributing to a team environment.

Qualifications

To qualify as a PostDoc, the applicant must have completed a Swedish doctoral degree or must have a foreign degree corresponding to a Swedish doctoral degree. A relevant background in Molecular Biology, Biochemistry, Biophysics, Structural Biology or related fields is expected. Previous work on related protein systems will be considered favorable. The successful candidate should have a strong background in biochemistry, biophysics, and/or NMR spectroscopy. Previous work with molecular chaperones and especially native vesicles, e.g. expression and purification and/or functional characterization for structural studies, will be considered an advantage.

  • Expert knowledge in recombinant protein expression and purification of relevant proteins (integral membrane and soluble proteins).
  • Expert knowledge in the preparation of bacterial vesicles
  • Expert knowledge in sample preparation (isotope labelling, methyl-labelling)
  • Expert knowledge in solution NMR methods (e.g. assignment, proteindynamics, data analysis)
  • Documented knowledge in automated data procession and analysis (resonance assignment, relaxation analysis etc.)
  • Detailed knowledge in additional biophysical and structural biology techniques (AFM, ITC, BLI, SEC-MALLS)
  • Working knowledge in additional structural biology methods (e.g. X-Ray, cryo-EM)

Employment

The employment is fixed term during 2 years, full time, 100 % at the Department of Chemistry and Molecular Biology

For further information regarding the position

Regarding the position, please contact
Björn Burmann, Associate Prof. (Docent), +46(0)31 786 3923 bjorn.marcus.burmann@gu.se

Unions

Union representatives at the University of Gothenburg:
https://www.gu.se/en/about-the-university/work-at-the-university-of-gothenburg/how-to-apply

Information for International Applicants

Choosing a career in a foreign country is a big step. Thus, to give you a general idea of what we and Gothenburg have to offer in terms of benefits and life in general for you and your family/spouse/partner please visit:

https://www.gu.se/en/about-the-university/welcome-services
https://www.movetogothenburg.com/

How to apply

In order to apply for a position at the University of Gothenburg, you have to register an account in our online recruitment system. It is the responsibility of the applicant to ensure that the application is complete in accordance with the instructions in the job advertisement, and that it is submitted before the deadline. The selection of candidates is made on the basis of the qualifications registered in the application. 

The application shall include:
Cover letter with an explanation of why you apply for the position

CV including scientific publications
Copy of exam certificate
Two referees (name, telephone no, relation)

Closing date: 2021-03-04

The University of Gothenburg promotes equal opportunities, equality and diversity.

Salary is determined on an individual basis.

Applications will be destroyed or returned (upon request) two years after the decision of employment has become final. Applications from the employed and from those who appeal the decision will not be returned.

In connection to this recruitment, we have already decided which recruitment channels we should use. We therefore decline further contact with vendors, recruitment and staffing companies.

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