Postdoctoral Fellow in Biology (Masaryk University)

We are seeking a talented and motivated candidate to join our team to pursue the mechanisms and functions of primary cilia. The primary cilium is an antenna-like organelle that has emerged as a fundamental regulator of embryonic development as well as tissue homeostasis. Consequently, the deregulation of its assembly, maintenance, or function leads to numerous human diseases, collectively termed ciliopathies. It has been estimated that cilia dysfunctions are responsible for as many as 100 human diseases. However, the mechanistic explanation of primary cilia assembly and function, crucial for the understanding of cilia-related defects and their therapeutic targeting, is insufficient. The successful candidate will join the lab of Laboratory of Cilia and Centrosome Biology (headed by Dr. Lukáš Čajánek) at Masaryk University in Brno. The lab has a long-term interest in revealing the molecular mechanisms of cilia assembly, maintenance, and cilia-mediated signaling, in particular in relation to 1) the components of so-called distal appendages and 2) molecular motors controlling ciliary trafficking. The selected applicant will have access to unique research tools, state-of-the-art methodology, and advanced instrumentation (cellular and animal models, proteomics, gene editing, lentiviral transduction, live cell imaging, super-resolution microscopy, etc.). For more information on the research themes in the lab, please visit: www.cajaneklab.com The successful candidate should: Hold a Ph.D. or its equivalent, awarded within the past 7 years, AND have worked in research for at least 2 years of work, within the last 3 years, outside the Czech Republic (with a workload equivalent to at least 0.5 full-time employment) Alternatively, hold a Ph.D. diploma (or equivalent) from an international institution awarded within the past 3 years Demonstrate a publication record that includes a minimum of three research outputs (articles) within the past three years, surpassing the field's median standards, with at least two of them ranked in Q1 according to Web of Science Specific qualifications include: Possess a Ph.D. in cell biology, molecular biology, or related fields Demonstrate a strong publication record in well-recognized scientific journals, including at least one first-author research article Exhibit expertise in mammalian cell culture, a wide array of molecular biology techniques, and advanced microscopy (skills in live cell imaging and/or super-resolution microscopy considered advantageous) Clearly demonstrate an interest in and an aptitude for addressing scientific challenges Be capable of independently planning experiments, prioritizing tasks, resolving project-related issues, and engaging in critical thinking Have exceptional communication and documentation skills Display a high level of motivation, creativity, proactivity, and self-driven initiative Include these in your application: A comprehensive CV, detailing your publication history A copy of your diploma A cover letter that encompasses the following: a) Highlight your most significant research contributions, explaining their importance and the impact they have had, b) Describe your research interests and outline your career aspirations, c) Explain your interest in this position, emphasizing the alignment and synergy between the host lab and your specific research background. Contact information for two referees who can provide insights into your qualifications Documentation confirming that you have accumulated a minimum of two full years of work experience outside the Czech Republic within the past three years, and/or a Ph.D. diploma from a foreign institution We offer: Access to Core Facilities and state-of-the-art facilities, including advanced imaging and sequencing technologies An exceptionally competitive salary, commensurate with the applicant's skills and proficiency. An enticing position within a rapidly evolving university precinct. A range of diverse and stimulating responsibilities within an outstanding research environment. An initial two-year appointment. The opportunity to collaborate with a professional team in a comfortable work environment. Interaction with renowned scientists within an inspiring, globally-connected setting. A dedicated welcome service tailored to the needs of the successful candidate and their family. Anticipated start date: The position is available from April 2025, or upon agreement The submission deadline is 31st January 2025 For more information, please contact Martina Vráblíková by e-mail vrablikova@med.muni.cz. The assessment of applications will begin promptly upon the deadline's closure. Candidates who make the shortlist will receive invitations for interviews within one month following the application deadline. Further information about: Medical Faculty is available at https://www.med.muni.cz/en Masaryk University is available at https://www.muni.cz/en Brno is available at https://www.gotobrno.cz/en/ If you apply for this position please say you saw it on Bioloxy

We are seeking a talented and motivated candidate to join our team to pursue the mechanisms and functions of primary cilia. The primary cilium is an antenna-like organelle that has emerged as a fundamental regulator of embryonic development as well as tissue homeostasis. Consequently, the deregulation of its assembly, maintenance, or function leads to numerous human diseases, collectively termed ciliopathies. It has been estimated that cilia dysfunctions are responsible for as many as 100 human diseases. However, the mechanistic explanation of primary cilia assembly and function, crucial for the understanding of cilia-related defects and their therapeutic targeting, is insufficient.

The successful candidate will join the lab of Laboratory of Cilia and Centrosome Biology (headed by Dr. Lukáš Čajánek) at Masaryk University in Brno. The lab has a long-term interest in revealing the molecular mechanisms of cilia assembly, maintenance, and cilia-mediated signaling, in particular in relation to 1) the components of so-called distal appendages and 2) molecular motors controlling ciliary trafficking.

The selected applicant will have access to unique research tools, state-of-the-art methodology, and advanced instrumentation (cellular and animal models, proteomics, gene editing, lentiviral transduction, live cell imaging, super-resolution microscopy, etc.).

For more information on the research themes in the lab, please visit: www.cajaneklab.com

The successful candidate should:

Hold a Ph.D. or its equivalent, awarded within the past 7 years, AND have worked in research for at least 2 years of work, within the last 3 years, outside the Czech Republic (with a workload equivalent to at least 0.5 full-time employment)
Alternatively, hold a Ph.D. diploma (or equivalent) from an international institution awarded within the past 3 years
Demonstrate a publication record that includes a minimum of three research outputs (articles) within the past three years, surpassing the field's median standards, with at least two of them ranked in Q1 according to Web of Science

Specific qualifications include:

Possess a Ph.D. in cell biology, molecular biology, or related fields
Demonstrate a strong publication record in well-recognized scientific journals, including at least one first-author research article
Exhibit expertise in mammalian cell culture, a wide array of molecular biology techniques, and advanced microscopy (skills in live cell imaging and/or super-resolution microscopy considered advantageous)
Clearly demonstrate an interest in and an aptitude for addressing scientific challenges
Be capable of independently planning experiments, prioritizing tasks, resolving project-related issues, and engaging in critical thinking
Have exceptional communication and documentation skills
Display a high level of motivation, creativity, proactivity, and self-driven initiative

Include these in your application:

A comprehensive CV, detailing your publication history
A copy of your diploma
A cover letter that encompasses the following: a) Highlight your most significant research contributions, explaining their importance and the impact they have had, b) Describe your research interests and outline your career aspirations, c) Explain your interest in this position, emphasizing the alignment and synergy between the host lab and your specific research background.
Contact information for two referees who can provide insights into your qualifications
Documentation confirming that you have accumulated a minimum of two full years of work experience outside the Czech Republic within the past three years, and/or a Ph.D. diploma from a foreign institution

We offer:

Access to Core Facilities and state-of-the-art facilities, including advanced imaging and sequencing technologies
An exceptionally competitive salary, commensurate with the applicant's skills and proficiency.
An enticing position within a rapidly evolving university precinct.
A range of diverse and stimulating responsibilities within an outstanding research environment.
An initial two-year appointment.
The opportunity to collaborate with a professional team in a comfortable work environment.
Interaction with renowned scientists within an inspiring, globally-connected setting.
A dedicated welcome service tailored to the needs of the successful candidate and their family.

Anticipated start date: The position is available from April 2025, or upon agreement
The submission deadline is 31st January 2025

For more information, please contact Martina Vráblíková by e-mail vrablikova@med.muni.cz.
The assessment of applications will begin promptly upon the deadline's closure. Candidates who make the shortlist will receive invitations for interviews within one month following the application deadline.

Further information about: