Postdoctoral Scientist for Molecular Biologist
The University of Sydney for The Heart Research Institute
Australia

Exciting opportunity exists to join a successful research group as part of a partnership between The Heart Research Institute and the University of Sydney's Charles Perkins Centre
Full-time, 12-month initial appointment with possibility of extension; A competitive remuneration package along with salary-packaging options
Located at Heart Research Institute, Charles Perkins Centre


About the opportunity

An exciting opportunity exists to join a successful research group as part of a partnership between The Heart Research Institute and the University of Sydneys Charles Perkins Centre, a world class research and education precinct that is addressing the global epidemic of obesity, diabetes and cardiovascular disease – the leading causes of mortality in Australia.


The Heart Research Institute is seeking a post-doctoral Molecular Biologist to contribute to innovative and collaborative research programs with a focus on cardiovascular genetics approaches to better understand the biology the vasculature. The position would be within the Atherosclerosis and Vascular Remodeling (AVRG) group, that uses genetic mouse models, lineage tracing, clonal analysis and primary cell culture to elucidate mechanisms and is creating new murine models to mimic vascular disease in human to be used to assess disease progression and to assess therapeutic targets that promote regression.


The Molecular Biologist would also support other groups in HRI in collaborative projects that required particular expertise in genetic techniques.


They will use state-of-the-art genetic techniques including traditional Cre-Lox conditional/tissue-specific knockouts, lineage tracing, clonal analysis, fluorescence activated cell sorting (FACS) and next generation sequencing techniques such as RNA seq, single-cell RNA seq.


You will be employed by the Heart Research Institute but will work at our premises at the Charles Perkins Centre located nearby at the University of Sydney when required. This is an outstanding opportunity to develop skills and gain valuable experience conducting innovative research in state-of-the-art facilities.


About you

The University values courage and creativity; openness and engagement; inclusion and diversity; and respect and integrity. As such, we see the importance of recruiting talent aligned to these values and are looking for a Postdoctoral Scientist-Molecular Biologist who meets the below:


Essential criteria – you will have:

A PhD in cell and molecular biology
In-depth knowledge in Cre-LoxP systems and mouse genetics
A knowledge of genomics approaches such as single-cell RNA seq, RNA seq and molecular biology
Some experience in FACS and cell sorting
Experience in small animal models and animal handling
A knowledge of cell/macrophage biology
A knowledge of confocal microscopy techniques
A strong interest and commitment in translational research and producing good quality publications
High levels of motivation and the capacity for independent work
A track record of being team focused
Good interpersonal, written, and oral communication skills



Desirable criteria – you will have:

Experience in in vivo models of cardiovascular disease
Experience in models of inflammation
Experience in animal surgery
Experience in in vitro cell culture and cell culture-based assays
In addition to the listed criteria, the successful candidate will be expected to contribute to the research program by performing a range of research-related tasks which may include the following:

 

Assist in the conduct and design of experiments
Assist in the general supervision of students in the laboratory
Assist in the preparation of documents (for grant applications, research/conference papers, ethics applications)
Provide administrative and financial management support for research projects and programs including the maintenance of electronic data bases and records
Maintain particular lab equipment and materials, including waste disposal and ordering supplies
Maintain occupational health and safety standards


About us

THE HEART RESEARCH INSTITUTE is a centre of excellence in cardiovascular medical research affiliated with the Royal Prince Alfred Hospital and the University of Sydney located in Newtown, Sydney. Our research is to understand the origins and mechanisms of cardiovascular diseases, including atherosclerosis and heart failure, and the contributions of diabetes and thrombosis.


THE CHARLES PERKINS CENTRE is facilitating world-class research; the translation of knowledge into practical solutions; the development of innovative, cross-disciplinary teaching programs to inspire the next generation of researchers; and forging new research partnerships within and beyond the University to enable the centre to deliver unique insights and results. This ambitious mission is underpinned by two key components:


An academic program that covers research and teaching
A state-of-the-art world-class building
The partnership between The Heart Research Institute and the Charles Perkins Centre brings together our best minds from across the academic spectrum through cross-disciplinary collaboration to develop innovative approaches to alleviating the burden of cardiovascular disease. For more information, visit The Heart Research Institute at http://www.hri.org.au and the Charles Perkins Centre at http://sydney.edu.au/perkins/


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