Postdoctoral studies in metabolism and genomic instability in cancer
Do you want to contribute to top quality medical research?The position is placed in the research team headed by Assistant Professor Nina Gustafsson at the Department of Oncology-Pathology situated at the Science for Life Laboratories. The research group is a creative and dedicated team that performs translational cancer research with focus on metabolic regulation of genome stability. We provide mentorship to help the candidate progress to a career as an independent researcher and have several collaborations involving world-leading researchers and clinicians, providing excellent network opportunities. We share laboratories with the research group headed by Professor Thomas Helleday and Deputy group leader Ulrika Warpman Berglund, which provides an excellent translational and scientific environment. The multidisciplinary research group is located at Science for Life Laboratory and includes PhD students, postdocs and senior scientists within biology, biochemistry, medicinal chemistry, and pharmacology, many with experience from the pharmaceutical industry. Your missionWe are looking for a postdoctoral researcher to drive an exciting research project investigating the novel relationship between metabolism and maintenance of genomic stability in cancer. We have identified a novel role for metabolic enzymes in driving cancer cell proliferation via regulation of the DNA damage response and developed a drug targeting one of these enzymes. However, the underlying mechanisms in the interplay between these two hallmarks of cancer are not clear. The project will focus on metabolism and the DNA damage response in cancer using state of the art models and techniques such as patient derived ex vivo cultures, organoids, CRISPR/Cas9 knockout, live-cell imaging and DNA fiber assays. The appointed person will be expected to plan, perform, analyse and interpret experimental results independently and within the team, present at scientific conferences and participate in national/international collaboration networks. The applicant is expected to be dedicated to full time experimental research and should maintain accurate and up to date research records. We anticipate that the project not only will results in novel, exciting scientific publications but also contribute towards new therapeutic approaches against cancer. Your profileQualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant's main supervisor, director or equivalent. The successful candidate should hold a PhD degree in biomedical, cell- or molecular biology. The applicant should have prior experience in molecular mechanisms of DNA repair and/or replication and relevant techniques. We are looking for a bright, ambitious and highly motivated researcher who can work well in a team, in a multidisciplinary and highly international and ethnically diverse laboratory. The applicant should have good social and analytical skills and be able to organise and prioritise research within the project timetable. The applicant should have excellent written and oral communication skills and be fluent in English, written and spoken. Emphasis will be placed on personal suitability. What do we offer?A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. Karolinska Institutet is a state university, which entitles to several benefits such as extended holiday and generous occupational pension. Employees also have access to our modern gym for free and receive reimbursements for medical care.
Department of Oncology-Pathology
ApplicationAn employment application must contain the following documents in English or Swedish:
Welcome to apply at the latest 2020-02-15. The application is to be submitted through the Varbi recruitment system.
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