Predoctoral researcher in Department of Biomolecular Medicine Ghent University, Department of Biomolecular Medicine Belgium

Predoctoral researcher


Last application date
Sep 15, 2019 11:47


Department
GE31 - Department of Biomolecular Medicine


Employment category
Research staff group 1


Contract
Limited duration


Degree
Master of Science in Bioscience Engineering, Master of Science in Biomedical Sciences, Master of Science in Biochemistry and Biotechnology, Master of Medicine, Master of Science in Pharmaceutical Sciences


Occupancy rate
100%


Vacancy Type
Research staff

 

Job description

A position is available in the research team on heritable thoracic aortic diseases (HTAD) at Ghent University, supervised by Prof. Dr. Julie De Backer and Dr. Patrick Sips (https://www.cmgg.be/en/research/connective-tissue/aortic-aneurysm), for a highly motivated, driven researcher with a strong interest in genetics and cardiovascular disease, and basic knowledge in the use of preclinical models. Since the advent of the latest DNA sequencing technologies, the clinical implementation of precision medicine for genetic disorders has come within reach. Nevertheless, the availability of relevant functional models to test the effects of newly discovered genetic variants has become a major bottleneck in medical genetics. On the other hand, suitable functional models are necessary for the discovery and validation of new treatment options. In order to address these issues in the framework of our focus on HTAD, you will be engaged in an ongoing preclinical research project. You will develop novel zebrafish models using genome editing technology to be able to perform genetic and pharmacologic screening programs. As a complementary model, you will also use existing genetically modified mouse models to validate results from the zebrafish screens and to test several new treatment options to alleviate the symptoms of HTAD. The techniques used in this project include CRISPR/Cas-based gene editing, advanced brightfield and fluorescence microscopy, in vivo high-throughput screening, mouse and zebrafish echocardiography, immunohistochemistry, Western blotting, and QPCR.

 

We offer:

  • a fully funded 4-year PhD fellowship (candidates will be encouraged to apply for FWO and BOF PhD grants).

  • participation in the rapidly evolving research area of precision medicine for genetic disorders.

  • the opportunity to work in a dynamic and interdisciplinary academic top-tier research environment with a strong link to the clinic and a broad range of expertise.

  • access to state-of-the-art research facilities.

  • the opportunity to benefit from the well-established PhD training program of the doctoral school at UGent.

 

Profile of the candidate

Job profile:

  • You obtained a Master of Science in Bioscience Engineering, Master of Science in Biomedical Sciences, Master of Science in Biochemistry and Biotechnology, Master of Medicine, Master of Science in Pharmaceutical Sciences, or equivalent degree.

  • You have a strong interest in genetics and/or cardiovascular research with a drive to learn and adopt a variety of new techniques.

  • An excellent background in life sciences and experience with basic research is desirable.

  • You have (or are willing to obtain) a FELASA Category C certificate to work with laboratory animals.

  • You are ambitious, practically skillful, able to work in a team setting, and have strong analytical problem-solving skills (creative, critical, and open-minded).

  • You have excellent oral and written communication skills, and are proficient in English.

  • A basic knowledge of Dutch is desirable but not mandatory.

 

How to apply

Applications including a CV with a description of research output and motivation letter should be sent electronically to htad.cmgg@uzgent.be.

Top-ranked candidates will be invited for an interview (either on-site or via Skype) during the first two weeks of September.

Starting date will be determined in agreement with the candidate.


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