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We are looking for a highly talented and motivated post-doctoral scientist to join the laboratory of Dr. Iva Tchasovnikarova at the Gurdon Institute, University of Cambridge. The overarching goal of the Tchasovnikarova lab is to apply novel genetic approaches to answer outstanding questions in epigenetics. Our research aims to (1) understand the molecular mechanisms utilised by chromatin regulators to exert their function in healthy human cells, and to (2) examine how these mechanisms are altered in disease. We take advantage of existing high-throughput genetic technologies, such as CRISPR/Cas9 genetic screens, to discover novel factors involved in chromatin pathways, which we then characterise using a combination of genetic and biochemical approaches. We are also particularly interested in developing novel genetic methods to study epigenetic pathways in human cells. Publications relevant to this position include: Tchasovnikarova IA et al (2015) Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells. Science, 348 (6242): 1481-5 Tchasovnikarova IA et al (2017) Hyperactivation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2. Nature Genetics, 49: 1035-1044 Further information can be found on the lab webpage, https://www.tchasovnikarova-lab.org You should be passionate about epigenetics, be willing to tackle difficult problems and be able to develop novel experimental approaches to answer outstanding questions in the field. While prior experience with cloning, mammalian cell culture, CRISPR genome editing, flow cytometry and next-generation sequencing would be advantageous, an eagerness to learn and to exploit and develop innovative methods is the critical requirement. You will play a key role in a small team, and so a friendly and collegial attitude is crucial. You should have a PhD in a relevant subject, or be close to completion of your degree. For further details or informal enquires please contact Iva via email (it257@cam.ac.uk). Fixed-term: The funds for this post are available for 18 months in the first instance. Please upload a CV, including the contact details of at least two referees, one of whom should be your PhD supervisor. You should also include a covering letter outlining your research interests, areas of expertise and reasons why you would like to join the lab. If you have any questions about this vacancy or the application process, please contact jobs@gurdon.cam.ac.uk. Please quote reference PR25337 on your application and in any correspondence about this vacancy. The University actively supports equality, diversity and inclusion and encourages applications from all sections of society. The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
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