Research Associate in Infectious Diseases (Imperial College London Department of Life Sciences)

Job summary We are looking to appoint a Research Associate in infectious diseases to join the Department of Life Sciences at Imperial College London. You will be joining Professor Frankel’s Group based in the MRC Centre for Bacteriology Microbiology and Infection (CMBI), located in the Flowers Building, South Kensington Campus. The CMBI is a centre of excellence housing several groups studying bacterial pathogenesis, secretion systems, virulence and... Job listing information Reference NAT01061 Date posted 5 January 2022 Closing date 2 February 2022 Key information about the role Location South Kensington Campus (map) Position type Full time, fixed term Salary £41,593 – £49,210 plus benefits Department Department of Life Sciences Category Researcher / Non Clinical Researcher Job description Job summary We are looking to appoint a Research Associate in infectious diseases to join the Department of Life Sciences at Imperial College London. You will be joining Professor Frankel’s Group based in the MRC Centre for Bacteriology Microbiology and Infection (CMBI), located in the Flowers Building, South Kensington Campus. The CMBI is a centre of excellence housing several groups studying bacterial pathogenesis, secretion systems, virulence and colonisation factors, gene expression, bacterial cell walls, toxins and biofilms. Enteric bacterial infections and inflammation are intimately linked with metabolism and the microbiome. Recent studies illustrated the fluidity of the pathogenic state, which could be tilted towards commensalism by changes to diet and the composition of the microbiota. Moreover, we have shown that infections are orchestrated by intracellular type III secretion system effector networks (Cell Metabol. 26 (2017), 738-752.e6; Cell Reports 20 (2017), 2201-2214; Science 371 (2021); eabc9531; mBio. 26 (2021), e0241021; ). You will use the natural mouse pathogen Citrobacter rodentium to model pathogen-host-microbiome interactions. Candidates interested in infection, pathogenesis, inflammation and metabolism are encouraged to apply. Duties and responsibilities You will be expected to perform the outlined experiments to a high standard. In particular, you will be expected to: Perform standard scientific techniques including cell culture, infection and in vivo mouse procedures To perform detailed inflammatory profiling of infection To conduct multiomic studies (g. metagenomics, transcriptomics and metabolomics) including large scale data analysis To conduct bioinformatic analysis To closely collaborate with specialists in ex vivo infection models (e.g. organoids) To ensure the validity, reliability and reproducibility of data at all times To present findings to colleagues and at conferences To write up the findings for submission to refereed journals Essential requirements You must hold a PhD degree (or equivalent) in Molecular Cell Biology, Infection, Microbiome or related disciplines. You must be able to demonstrate experience in the following areas: Molecular biology and biochemistry In vivo mouse work (a Home Office personal animal licence is desirable, but not essential) Bioinformatics/data analysis You must be able to demonstrate knowledge in the following areas: Cell biology of infection Statistical and image analyses Pathogen host interactions It is essential that you have: The ability to work as part of a team and be open minded and cooperative The ability to develop and apply new concepts and have a creative approach to problem solving Excellent verbal and written communication skills The ability to organise your own work with minimal supervision and prioritise in response to deadlines. Further information This is a full time, fixed-term position until 31 December 2023. You will be based at South Kensington Campus. Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant within the salary range £36,694 - £39,888 per annum. Informal enquiries can be made directly to Professor Gad Frankel, Tel +44 20 7594 5253; email: g.frankel@imperial.ac.uk. The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA),* which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/ The College believes that the use of animals in research is vital to improve human and animal health and welfare. Animals may only be used in research programmes where their use is shown to be necessary for developing new treatments and making medical advances. Imperial is committed to ensuring that, in cases where this research is deemed essential, all animals in the College’s care are treated with full respect, and that all staff involved with this work show due consideration at every level. /www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-integrity/animal-research/ If you apply for this position please say you saw it on Bioloxy

Job summary

We are looking to appoint a Research Associate in infectious diseases to join the Department of Life Sciences at Imperial College London. You will be joining Professor Frankel’s Group based in the MRC Centre for Bacteriology Microbiology and Infection (CMBI), located in the Flowers Building, South Kensington Campus. The CMBI is a centre of excellence housing several groups studying bacterial pathogenesis, secretion systems, virulence and...

Job listing information

Reference NAT01061
Date posted 5 January 2022
Closing date 2 February 2022

Key information about the role

Location South Kensington Campus (map)
Position type Full time, fixed term
Salary £41,593 – £49,210 plus benefits
Department Department of Life Sciences
Category Researcher / Non Clinical Researcher

Job description

Job summary

Enteric bacterial infections and inflammation are intimately linked with metabolism and the microbiome. Recent studies illustrated the fluidity of the pathogenic state, which could be tilted towards commensalism by changes to diet and the composition of the microbiota. Moreover, we have shown that infections are orchestrated by intracellular type III secretion system effector networks (Cell Metabol. 26 (2017), 738-752.e6; Cell Reports 20 (2017), 2201-2214; Science 371 (2021); eabc9531; mBio. 26 (2021), e0241021; ).

You will use the natural mouse pathogen Citrobacter rodentium to model pathogen-host-microbiome interactions.

Candidates interested in infection, pathogenesis, inflammation and metabolism are encouraged to apply.

Duties and responsibilities

You will be expected to perform the outlined experiments to a high standard. In particular, you will be expected to:

Perform standard scientific techniques including cell culture, infection and in vivo mouse procedures
To perform detailed inflammatory profiling of infection
To conduct multiomic studies (g. metagenomics, transcriptomics and metabolomics) including large scale data analysis
To conduct bioinformatic analysis
To closely collaborate with specialists in ex vivo infection models (e.g. organoids)
To ensure the validity, reliability and reproducibility of data at all times
To present findings to colleagues and at conferences
To write up the findings for submission to refereed journals

Essential requirements

You must hold a PhD degree (or equivalent) in Molecular Cell Biology, Infection, Microbiome or related disciplines.

You must be able to demonstrate experience in the following areas:

Molecular biology and biochemistry
In vivo mouse work (a Home Office personal animal licence is desirable, but not essential)
Bioinformatics/data analysis

You must be able to demonstrate knowledge in the following areas:

Cell biology of infection
Statistical and image analyses
Pathogen host interactions

It is essential that you have:

The ability to work as part of a team and be open minded and cooperative
The ability to develop and apply new concepts and have a creative approach to problem solving
Excellent verbal and written communication skills
The ability to organise your own work with minimal supervision and prioritise in response to deadlines.

Further information

This is a full time, fixed-term position until 31 December 2023. You will be based at South Kensington Campus.

*Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant within the salary range £36,694 - £39,888 per annum.

Informal enquiries can be made directly to Professor Gad Frankel, Tel +44 20 7594 5253; email: g.frankel@imperial.ac.uk.

The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/

The College believes that the use of animals in research is vital to improve human and animal health and welfare. Animals may only be used in research programmes where their use is shown to be necessary for developing new treatments and making medical advances. Imperial is committed to ensuring that, in cases where this research is deemed essential, all animals in the College’s care are treated with full respect, and that all staff involved with this work show due consideration at every level. /www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-integrity/animal-research/

If you apply for this position please say you saw it on Bioloxy

Apply

All Jobs