Research Fellow in Dementia Research
University College London
United Kingdom

UCL Queen Square Institute of Neurology

UK Dementia Research Institute at UCL

Research Fellow

 

Dementia is the greatest health challenge of our century.

To date there is no way to prevent it or even slow its progression, and there is an urgent need to fill the knowledge gap in our basic understanding of the diseases that cause it.

The UK Dementia Research Institute (UK DRI) is the biggest UK initiative driving forward research to fill this gap.

Tim Bartels first discovered disease resistant forms of the α-synuclein protein and their destabilisation in Parkinson’s Disease. His lab is interested in identifying the different factors that destabilise α-synuclein and that lead to neurotoxicity.

 

We’re now offering an exciting opportunity to join the lab as a Research Fellow working on one of the current projects on offer. One project will involve developing antibodies against specific species of α-Synuclein, a protein involved in neurodegeneration, and developing an ELISA or Quanterix detection assay to detect α-Synuclein in different human biofluids (blood, CSF) and establishing a fluid biomarker for Parkinson’s Disease and Dementia with Lewy Bodies. This project will offer the opportunity o work  in collaboration with Zetterberg lab at the UK DRI at UCL and Rimona Weil at the National Hospital for Neurology and Neurosurgery. The second project involves investigating the gut-brain axis in PD using mouse models and human synucleinopathy tissue in collaboration with the Soyon Hong lab at the UK DRI. Candidates interested in this project should be familiar with one (or more) of the following: Protein biochemistry (Western, ELISA, IHC), biophysical structure work, protein purification, immune cell signalling.

 

The post is available from September 2022 and is funded by the UK DRI at UCL for one year in the first instance.

The post is offered full time, with salary in the range of £36,770 - £44,388 per annum inclusive of London Allowance. The Institute also offers 41 days of annual leave (inclusive of bank holidays and college closure dates), a generous pension scheme, access to UCL’s community benefits including lunch-hour lectures, exhibitions, and museums, as well as an extensive range of staff benefits.

You will have a PhD or MD in Biophysics, Biochemistry or Molecular Biology, be a good communicator, have strong interpersonal skills, and be a proactive and creative thinker.

Appointment at Grade 7 is dependent upon having been awarded a PhD; if this is not the case, initial appointment will be at Research Assistant Grade 6B (salary £32,217 - £33,958 per annum) with payment at Grade 7 being backdated to the date of final submission of the PhD thesis.

For further details, including the full job description and person specification, please visit UCL’s online recruitment portal using job reference 1879783.

If you have any queries regarding the vacancy or the application process, please contact the ION HR team at ion.hradmin@ucl.ac.uk. For informal enquiries about the role please contact Tim Bartels (t.bartels@ucl.ac.uk).

Closing date:  23:59, 31 July 2022

We particularly welcome applications from black and minority ethnic candidates as they are under-represented within UCL at this level.

We will consider applications to work on a part-time, flexible and job share basis wherever possible.


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